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Predicting Cancer Chemosensitivity Based on Intensity/Distribution Profiles of Cells Loaded with a Fluorescent Sphingolipid Analogue
Cancer is a group of heterogeneous and complex diseases, with limited therapeutic options due to the recurrent emergence of drug resistance. Sphingolipids are bioactive molecules that participate in signaling of cell ...
Characterization of heterogeneous response to chemotherapy by perturbation-based modeling of fluorescent sphingolipid metabolism in cancer cell subpopulations
Cancer treatments options are limited by the generation of therapy resistance, which is due by intratumoral heterogeneity in cell response. The study of resistance requires biosensors able to report the response at the ...
Identification of cancer chemosensitivity by ODE and GMM modeling of heterogeneous cellular response to perturbations in fluorescent sphingolipid metabolism
Cancer refers to a group of diseases in which cells display uncontrolled growth. Chemotherapy options are usually conditioned by generating resistance which is explained in part by the intrinsic heterogeneity of the ...
Shigellosis in Central America
(Shigellosis: a continuing global problem:ICDDR,Bangladesh p 26-38, 1983)
Shigella infections are very common in Central America, except in Costa Rica and Panama where prevalence rates are low. Shigellosis is the most serious among all the specific diarrhoeas, due to its invasive character, systemic ...
Hybrid mathematical modeling decodes the complexity of sphingolipid pathway to predict chemosensitivity
Sphingolipid (SL) signaling pathway is a complex biological system able to integrate different types of cellular stress signals related to induction of cell death pathways with special interest in cancer. This makes of ...