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Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms 

Segura Ruiz, Álvaro; Castillo, M. C.; Núñez Rangel, Vitelbina; Yarlequé, A.; Gonçalves, Luís Roberto de Camargo; Villalta Arrieta, Mauren; Bonilla, César; Herrera Vega, María; Fernández, M.; Yano, M. Y.; Araújo, H. P.; Boller, M. A. A.; León, P.; Sano Martins, I. S.; Gómez, A.; Fernández, Gil Patrick; Geoghegan, Patricia; Higashi, Hisako Gondo; León Montero, Guillermo; Gutiérrez, José María; Tintaya, Benigno (2010-11)
Species of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, ...

Venom variation in Bothrops asper lineages from north-western South America. 

Mora Obando, Diana; Salazar Valenzuela, David; Pla Ferrer, Davinia; Lomonte, Bruno; Guerrero Vargas, Jimmy; Ayerbe, Santiago; Gibbs, H. Lisle; Calvete Chornet, Juan José (2020)
Bothrops asper is a venomous pitviper that is widely distributed and of clinical importance in Mesoamerica and northern South America, where it is responsible for 50–80% of all envenomations by Viperidae species. Previous ...

Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity 

Zuliani, Juliana Pavan; Fernandes, Cristina Maria; Zamunér, Stella Regina; Gutiérrez, José María; Teixeira, Catarina de Fátima (2005-03)
The inflammatory events induced in the peritoneal cavity of mice by two PLA2s isolated from Bothrops asper snake venom were investigated. MT-III, an Asp-49 catalytically active enzyme and MT-II, a catalytically inactive ...
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Bases moleculares del reconocimiento de antígenos 

Lomonte, Bruno (1999)
Aunque todos los organismos pertenecientes al reino animal poseen una serie de mecanismos inmunitarios que persiguen mantener su integridad y rechazar la invasión de material foráneo, solo los vertebrados cuentan con un ...

A new method for the detection of phospholipase A2 variants: identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes 

Moreno Robles, Edgardo; Alape Girón, Alberto; Sánchez, Manuel; Gutiérrez, José María (1988)
A new method for the identification of phospholipase A2 isozymes in snake venoms is described. The technique is based on the separation of the venom components by isoelectric focusing in agarose gels, transfer of the protein ...

The Global Snake Bite Initiative: an antidote for snake bite 

Williams, David J.; Gutiérrez, José María; Harrison, Robert A.; Warrell, David A.; White, Julian; Winkel, Kenneth D.; Gopalakrishnakone, Ponnampalam (2010-01-02)
Clinicians have for a long time witnessed the tragedy of injury, disability, and death from snake bite that is a daily occurrence in many parts of Africa, Asia, and Latin America. To many people living in these ...

Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA 

Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Franceschi, Aida; Chaves Mora, Fernando; León Montero, Guillermo; Cury, Yara; Ovadia, Michael; Gutiérrez, José María (2000-11)
The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice. Both ...

Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation. 

Gutiérrez, José María; León Montero, Guillermo; Lomonte, Bruno (2003-07)
Parenteral administration of horse- and sheep-derived antivenoms constitutes the cornerstone in the therapy of envenomations induced by animal bites and stings. Depending on the type of neutralising molecule, antivenoms ...
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Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: Comparison with two commercial antivenoms 

Otero Patiño, Rafael; Núñez Rangel, Vitelbina; Gutiérrez, José María; Robles, Abel; Estrada Umaña, Ricardo; Osorio, Raúl Guillermo; Del Valle, G.; Valderrama, R.; Giraldo, Cesar Augusto (1997-04)
Three horse-derived antivenoms were tested for their ability to neutralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxic activities induced by the venom of Bothrops atr-ox from Antioquia and Choco (Colombia). ...
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The sexist beliefs that underlie in the pedagogy about obesity in physical education classes 

Núñez Rivas, Hilda Patricia; Holst Schumacher, Ileana; Campos Saborío, Natalia; Alfaro Mora, Flory Virginia (2019)
The physical education class and the teachers guide to this subject are key elements to make physical activity a habit for life. This article describes the sexist beliefs that underlie in the pedagogy about obesity in ...
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AuthorGutiérrez, José María (400)Lomonte, Bruno (326)Calvete Chornet, Juan José (73)Troyo Rodríguez, Adriana (72)Angulo Ugalde, Yamileth (67)Rucavado Romero, Alexandra (67)León Montero, Guillermo (62)Calderón Arguedas, Ólger (59)Fernández Ulate, Julián (46)Sanz, Libia (45)... View MoreType
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