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Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms
(2010-11)
Species of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, ...
Venom variation in Bothrops asper lineages from north-western South America.
(2020)
Bothrops asper is a venomous pitviper that is widely distributed and of clinical importance in Mesoamerica and northern South America, where it is responsible for 50–80% of all envenomations by Viperidae species. Previous ...
Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity
(2005-03)
The inflammatory events induced in the peritoneal cavity of mice by two PLA2s isolated from Bothrops asper snake venom were investigated. MT-III, an Asp-49 catalytically active enzyme and MT-II, a catalytically inactive ...
Bases moleculares del reconocimiento de antígenos
(1999)
Aunque todos los organismos pertenecientes al reino animal poseen una serie de mecanismos inmunitarios que persiguen mantener su integridad y rechazar la invasión de material foráneo, solo los vertebrados cuentan con un ...
A new method for the detection of phospholipase A2 variants: identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes
(1988)
A new method for the identification of phospholipase A2 isozymes in snake venoms is described. The technique is based on the separation of the venom components by isoelectric focusing in agarose gels, transfer of the protein ...
The Global Snake Bite Initiative: an antidote for snake bite
(2010-01-02)
Clinicians have for a long time witnessed the tragedy of
injury, disability, and death from snake bite that is a daily
occurrence in many parts of Africa, Asia, and Latin
America. To many people living in these ...
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA
(2000-11)
The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice. Both ...
Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation.
(2003-07)
Parenteral administration of horse- and sheep-derived antivenoms constitutes the cornerstone in the therapy of envenomations induced by animal bites and stings. Depending on the type of neutralising molecule, antivenoms ...
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: Comparison with two commercial antivenoms
(1997-04)
Three horse-derived antivenoms were tested for their ability to neutralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxic activities induced by the venom of Bothrops atr-ox from Antioquia and Choco (Colombia). ...
The sexist beliefs that underlie in the pedagogy about obesity in physical education classes
(2019)
The physical education class and the teachers guide to this subject are key elements to make physical activity a habit for life. This article describes the sexist beliefs that underlie in the pedagogy about obesity in ...