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Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis 

Sanz, Libia; Escolano, José; Ferretti, Massimo; Biscoglio, Mirtha J.; Rivera, Elena; Crescenti, Ernesto J.; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Calvete Chornet, Juan José (2008-04-30)
We report the proteomic characterization of the venoms of two closely related pit vipers of the genus Lachesis, L. muta (South American Bushmaster) and L. stenophrys (Central American Bushmaster), and compare the toxin ...
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Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead 

Solano Trejos, María Gabriela; Pla Ferrer, Davinia; Herrera Vega, María; Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Sánchez Brenes, Andrés; Sanz, Libia; Lomonte, Bruno; León Montero, Guillermo; Calvete Chornet, Juan José; Gutiérrez, José María (2017-05)
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous ...

Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America 

Calvete Chornet, Juan José; Sanz, Libia; Cid, Pedro; De La Torre, Pilar; Flores Díaz, Marietta; Dos Santos, María Cristina; Borges, Adolfo; Bremo, Adolfo; Angulo Ugalde, Yamileth; Lomonte, Bruno; Alape Girón, Alberto; Gutiérrez, José María (2010)
We report a comparative venomic and antivenomic characterization of the venoms of newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of the subspecies cumanensis, durissus, ruruima, and ...
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Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus 

Durban, Jordi; Pérez, Alicia; Sanz, Libia; Gómez Argüello, Aarón; Bonilla Murillo, Fabián; Rodríguez Arguedas, Santos; Chacón Gutiérrez, Danilo; Sasa Marín, Mahmood; Angulo Ugalde, Yamileth; Gutiérrez, José María; Calvete Chornet, Juan José (2013)
Background Understanding the processes that drive the evolution of snake venom is a topic of great research interest in molecular and evolutionary toxinology. Recent studies suggest that ontogenetic changes in venom ...
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Snake venomics of crotalus tigris: the minimalist toxin arsenal of the deadliest neartic rattlesnake venom: evolutionary clues for generating a pan-specific antivenom against crotalid type II venoms 

Calvete Chornet, Juan José; Pérez, Alicia; Lomonte, Bruno; Sánchez, Elda; Sanz, Libia (Journal of Proteome Research 11(2): 1382–1390, 2012-02-03)
We report the proteomic and antivenomic characterization of Crotalus tigris venom. This venom exhibits the highest lethality for mice among rattlesnakes and the simplest toxin proteome reported to date. The venom proteome ...
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Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms 

Calvete Chornet, Juan José; Sanz, Libia; Pla Ferrer, Davinia; Lomonte, Bruno; Gutiérrez, José María (Toxins vol.6:3388-3405, 2014-12-15)
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact worldwide, mostly affecting poor people involved in agricultural activities in Africa, Asia, Latin America and Oceania. A ...

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management 

Calvete Chornet, Juan José; Sanz, Libia; Pérez, Alicia; Borges, Adolfo; Vargas, Alba M.; Lomonte, Bruno; Angulo Ugalde, Yamileth; Gutiérrez, José María; Chalkidis, Hipócrates M.; Mourão, Rosa H.V.; Furtado, María de Fátima; Moura Da Silva, Ana M. (2011-04-11)
We describe two geographically differentiated venom phenotypes across the wide distribution range of Bothrops atrox, from the Colombian Magdalena Medio Valley through Puerto Ayacucho and El Paují, in the Venezuelan States ...

Venomics of the poorly studied hognosed pitvipers Porthidium arcosae and Porthidium volcanicum 

Ruiz Campos, Marco; Sanz, Libia; Bonilla Murillo, Fabián; Sasa Marín, Mahmood; Lomonte, Bruno; Zaruma Torres, Fausto Leonardo; Terán Zavala, María Del Carmen; Fernández Ulate, Julián; Calvete Chornet, Juan José; Caldeira, Cleópatra A. S.; da Silva, Saulo Luís (2021)
We report the first proteomics analyses of the venoms of two poorly studied snakes, the Manabi hognosed pitviper Porthidium arcosae endemic to the western coastal province of Manabí (Ecuador), and the Costa Rican hognosed ...

Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis 

Pla Ferrer, Davinia; Sanz, Libia; Molina Sánchez, Pedro; Zorita, Virginia; Madrigal Villalobos, Marvin; Flores Díaz, Marietta; Alape Girón, Alberto; Núñez Rangel, Vitelbina; Andrés, Vicente; Gutiérrez, José María; Calvete Chornet, Juan José (2013-08-26)
We report the proteomic analysis of the Atlantic bushmaster, Lachesis muta rhombeata, from Brazil. Along with previous characterization of the venom proteomes of L. stenophrys (Costa Rica), L. melanocephala (Costa Rica), ...

Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil 

Jorge, Roberta Jeane B.; Monteiro, Helena S. A.; Gonçalves Machado, Larissa; Guarnieri, Míriam C.; Ximenes, Rafael M.; Borges Nojosa, Diva M.; de O. Luna, Karla P.; Zingali, Russolina B.; Corrêa Netto, Carlos; Gutiérrez, José María; Sanz, Libia; Calvete Chornet, Juan José; Pla Ferrer, Davinia (2015-01-30)
The Caatinga lancehead, Bothrops erythromelas, is a medically relevant species, responsible for most of the snakebite accidents in most parts of its distribution range in northeastern Brazil. The spectrum and geographic ...
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AuthorCalvete Chornet, Juan José (48)Sanz, Libia (48)Gutiérrez, José María (40)Lomonte, Bruno (35)Angulo Ugalde, Yamileth (17)Pla Ferrer, Davinia (17)Fernández Ulate, Julián (13)Pérez, Alicia (9)Sasa Marín, Mahmood (9)Alape Girón, Alberto (8)... View MoreTypeartículo científico (45)artículo de revisión (1)capítulo de libro (1)preprint (1)ProcedenceVicerrectoría de Investigación (48)Vicerrectoría de Docencia (6)... View MoreHas File(s)Yes (48)

  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
  • Biblioteca Digital Carlos Melendez (CIHAC)
  • Repositorio de Fotografías
  • Colección de videos de UPA-VAS
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  • @Ciencia_UCR
  • Sobre Kérwá
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  • Políticas
Contact Us | Send Feedback
Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.