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South American snake venom proteins antigenically-related to Bothrops asper myotoxins.
(1990)
the presence of proteins antigenically related to Bothrops asper myotoxins in various snake venoms, mainly from South America, was investigated by using poluclonal and monoclonal antibodies. 2. Myotoxin-like components ...
Tissue Damage and Inflammation Induced by Snake Venoms
(2014-03-27)
Some characteristics of the local tissue damage and inflammatory reactions
induced by snake venoms were analyzed in a mouse model. Tissue damage was
studied by intravital, light, and electron microscopic techniques, and ...
Electrophoretic and immunochemical studies of Micrurus venoms
(1994)
The electrophoretic mobilities of venom components from 15 Micrurus species were studied by polyacrylamide gel electrophoresis. The venoms showed species-specific protein patterns under native (PAGE) or denaturing (urea-PAGE) ...
Inhibition of the myotoxic activity of Bothrops aspermyotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129
(1999)
The region comprising amino acid residues 115±129 of myotoxin II, a Lys49
phospholipase A2 from the venom of Bothrops asper, was previously shown to constitute a
heparin binding site, and to be associated with its toxic ...
Three-finger toxins from the venom of Micrurus tschudii (desert coral snake): isolation and characterization of tschuditoxin-I
(2019)
Venoms from Micrurus (New World coral snakes) display potent peripheral neurotoxicity which may cause death
by respiratory paralysis, yet many are poorly or not characterized. The major venom components of coral snakes
are ...
Venomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venoms
(2016)
The venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii
was unveiled using a venomic approach, which identified ¥38 proteins belonging to only four snake
venom protein families. The ...
Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of Bothrops asper snake venom
(1994)
The cytotoxic activity of Bothrops asper myotoxin II, a lysine-49 phospholipase A2 isoform, on different cell types in culture, was investigated. Myotoxin II caused a dose-dependent cytolytic effect on all cell types tested, ...
Proteomic and toxicological profiling of the venom of Bothrocophias campbelli, a pitviper species from Ecuador and Colombia
(Toxicon 90, 2014)
Detailed snake venom proteomes for nearly a hundred species in different pitviper genera have accumulated using ‘venomics’ methodologies. However, venom composition for some lineages remains poorly known. Bothrocophias ...
Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib
(2023)
Varespladib (LY315920) is a potent inhibitor of human group IIA phospholipase A2 (PLA2) originally developed to control inflammatory cascades of diseases associated with high or dysregulated levels of endogenous PLA2. ...
Primary structures and partial toxicological characterization of two phospholipases A2 from Micrurus mipartitus and Micrurus dumerilii coral snake venoms
(2017-06)
Snake venom phospholipases A2 (PLA2) share high sequence identities and a conserved structural scaffold, but show important functional differences. Only a few PLA2s have been purified and characterized from coral snake ...