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Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins
(2015-06)
The venom proteome of the monocled cobra, Naja kaouthia, from Thailand, was characterized by RPHPLC,
SDS-PAGE, and MALDI-TOF-TOF analyses, yielding 38 different proteins that were either identified
or assigned to families. ...
Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae)
(2011-01-31)
The proteome of the venom of Micrurus nigrocinctus (Central American coral snake) was analyzed by a “venomics” approach. Nearly 50 venom peaks were resolved by RP-HPLC, revealing a complex protein composition. Comparative ...
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
(2019)
A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms,
responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering
...
Proteomic and toxicological analysis of the venom of Micrurus yatesi and its neutralization by an antivenom
(2022)
Coralsnakes belong to the family Elapidae and possess venoms which are lethal to humans and can be grouped based on the predominance of either three finger toxins (3FTxs) or phospholipases A2 (PLA2s). A proteomic and ...
Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom
(2008-10)
The venom proteomes of the snakes Bothrops caribbaeus and Bothrops lanceolatus, endemic to the
Lesser Antillean islands of Saint Lucia and Martinique, respectively, were characterized by reversephase
HPLC fractionation, ...
Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms
(2018-06)
Snakebite envenoming by viperid species, and by some elapids, is characterized by a complex pattern of
tissue damage at the anatomical site of venom injection. In severe cases, tissue destruction may be so
extensive as ...
Why myotoxin-containing snake venoms possess powerful nucleotidases?
(2013-01-25)
The venom of the snake Bothrops asper causes muscle necrosis, pain and inflammation. This venom contains myotoxins which cause an increase in intracellular Ca2+ concentration and release of K+ and ATP from myotubes. ATP ...
Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus
(2021-09)
Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle ...
First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis
(Toxicon vol 93:144–154, 2015-01)
Bothriechis nigroviridis is an arboreal Neotropical pitviper found in Costa Rica and Panam a. A previous
proteomic profiling of its venom revealed the presence of proteins with homology to the A and B subunits
of ...
Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A2 ex vivo does not involve a direct action on the contractile apparatus
(2023)
Myonecrosis is a frequent clinical manifestation of envenomings by Viperidae snakes, mainly caused by the toxic actions of
secreted phospholipase A2
(
sPLA2) enzymes and sPLA2-
like homologs on skeletal muscle fibers. ...