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Membrane-damaging and cytotoxic sphingomyelinases and phospholipases
(2015-06-05)
This chapter presents an overview of the classification, structure, and main physiopathological activities of bacterial sphingomyelinases and phospholipases, providing examples of their roles as virulence factors in several ...
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
(2021-09)
The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis.
Although several SARS-CoV-2 vaccines have ...
The Phospholipase A2 Homologues of Snake Venoms: Biological Activities and Their Possible Adaptive Roles
(2009)
A particular subgroup of toxins with phospholipase A2 (PLA2) structure, but devoid of this enzymatic activity, is commonly found in the venoms of snakes of the family Viperidae, and known as the PLA2 homologues. Among ...
Clinical profiles at the time of diagnosis of COVID-19 in Costa Rica during the pre-vaccination period using a machine learning approach
(2021)
Background: The clinical manifestations of COVID-19 disease, caused by the SARS-CoV-2
virus, define a large spectrum of symptoms that are mainly dependent on the human host
conditions. In Costa Rica, almost 319 000 cases ...
Venom characterization of the bark scorpion Centruroides edwardsii (Gervais 1843): composition, biochemical activities and in vivo toxicity for potential prey
(2019)
In this study, we characterize the venom of Centruroides edwardsii, one of the most abundant scorpions in urban
and rural areas of Costa Rica, in terms of its biochemical constituents and their biological activities. C. ...
Porcentaje y cifra absoluta de linfocitos T en sangre periférica por el método de rosetas E: estudio de cuarenta adultos sanos
(1985)
Se realizó la determinación del porcentaje y cifra absoluta de linfocitos T en sangre periférica a un grupo de 40 adultos sanos costarricenses, seleccionados de un grupo inicial de 58 voluntarios. Se utilizó un método de ...
Population Genomics Insights into Adaptive Evolution and Ecological Differentiation in Streptomycetes
(2019)
Deciphering the genomic variation that represents microevolutionary processes toward species divergence is key to understanding microbial speciation, which has long been under debate. Streptomycetes are filamentous bacteria ...
Phylogenetic analyses of antibiotic-producing Streptomyces sp. isolates obtained from the stingless-bee Tetragonisca angustula (Apidae: Meliponini)
(2019)
Many insects have been associated with actinobacteria in protective symbiosis where antimicrobial metabolites inhibit host pathogens. However, the microbiota of neotropical insects such as the stingless-bee Tetragonisca ...
Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment
(2009)
Interest in studies on the neutralization of snake venoms and toxins by diverse types of
inhibitors is two-fold. From an applied perspective, results enclose the potential to be
translated into useful therapeutic products ...
Mevalonate pathway as a novel target for the treatment of metastatic gastric cancer
(2020-10)
Gastric mucosa tumors may present as two distinct major entities: Diffuse and intestinal subtypes. There is no
standard treatment for advanced or metastatic gastric cancer. The mevalonate pathway and cholesterol homeostasis ...