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Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect

Díaz Oreiro, Cecilia; Alape Girón, Alberto; Lomonte, Bruno; Olamendi Portugal, Timoteo; Gutiérrez, José María (1994-08)

Bothrops asper myotoxin II was cleaved with cyanogen bromide to determine the role of NH2-terminal amino acid residues in its ability to destabilize negatively charged liposomes and to induce myonecrosis. After treatment, ...

In vitro Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors

Rojas Jiménez, Gabriel; Solano Centeno, Daniela; Segura Ruiz, Álvaro; Sánchez Brenes, Andrés; Chaves Araya, Stephanie; Herrera Vega, María; Vargas Arroyo, Mariángela; Cerdas Solís, Maykel; Calvo Salas, Gerardo; Alfaro Alvarado, Jonathan A.; Bolaños Céspedes, Kimberly; Moreira Soto, Andrés; Villalta Arrieta, Mauren; Sánchez Sánchez, Adriana; Cordero Vásquez, Daniel; Durán Blanco, Gina; Solano Blanco, María Gabriela; Gómez Argüello, Aarón; Hernández Bolaños, Andrés; Sánchez Céspedes, Laura Vanessa; Vargas Soto, Marco; Drexler, Jan Felix; Alape Girón, Alberto; Díaz Oreiro, Cecilia; León Montero, Guillermo (2022)

Despite vaccines are the main strategy to control the ongoing global COVID-19 pandemic, their effectiveness could not be enough for individuals with immunosuppression. In these cases, as well as in patients with ...

Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19

Alape Girón, Alberto; Moreira Soto, Andrés; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Gómez Argüello, Aarón; Hernández Bolaños, Andrés; Herrera Vega, María; León Montero, Guillermo; Macaya Hayes, Román; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Narayanan, Aarthi; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Drexler, Jan Felix; Gutiérrez, José María (2021-09)

The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis. Although several SARS-CoV-2 vaccines have ...

High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern

Moreira Soto, Andrés; Gutiérrez, José María; Alape Girón, Alberto; Drexler, Jan Felix; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Macaya Hayes, Román; Kühne, Arne; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Reusken, Chantal B. E. M.; Drosten, Christian (2021)

SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) ...