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Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis 

Laustsen, Andreas Hougaard; Gutiérrez, José María; Rasmussen, Arne R.; Engmark, Mikael Gerling; Gravlund, Peter; Sanders, Kate L.; Lohse, Brian; Lomonte, Bruno (2015-12-01)
Four specimens of the olive sea snake, Aipysurus laevis, were collected off the coast of Western Australia, and the venom proteome was characterized and quantitatively estimated by RP-HPLC, SDS-PAGE, and MALDI-TOF-TOF ...

Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score 

Laustsen, Andreas Hougaard; Lohse, Brian; Lomonte, Bruno; Engmark, Mikael Gerling; Gutiérrez, José María (2015-09-15)
For more than 100 years, antivenoms have been produced by traditional methods of immunization of large mammals with mixtures of snake venoms (World Health Organization, 2010 and Gutiérrez et al., 2011). With the introduction ...

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: identification of key toxin targets for antivenom development. 

Laustsen, Andreas Hougaard; Lomonte, Bruno; Lohse, Brian; Fernández Ulate, Julián; Gutiérrez, José María (2015-04-24)
The venom proteome of the black mamba, Dendroaspis polylepis, from Eastern Africa, was, for the first time, characterized. Forty- different proteins and one nucleoside were identified or assigned to protein families. The ...
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Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus 

Laustsen, Andreas Hougaard; Engmark, Mikael Gerling; Clouser, Christopher; Timberlake, Sonia; Vigneault, Francois; Gutiérrez, José María; Lomonte, Bruno (2017)
Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom ...

Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps). 

Lauridsen, Line Præst; Laustsen, Andreas Hougaard; Lomonte, Bruno; Gutiérrez, José María (2016-03-16)
A toxicovenomic study was performed on the venom of the green mamba, Dendroaspis angusticeps. Forty-two different proteins were identified in the venom of D. angusticeps, in addition to the nucleoside adenosine. The most ...

Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins 

Laustsen, Andreas Hougaard; Gutiérrez, José María; Lohse, Brian; Rasmussen, Arne R.; Fernández Ulate, Julián; Milbo, Christina; Lomonte, Bruno (2015-06)
The venom proteome of the monocled cobra, Naja kaouthia, from Thailand, was characterized by RPHPLC, SDS-PAGE, and MALDI-TOF-TOF analyses, yielding 38 different proteins that were either identified or assigned to families. ...

Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca 

Lauridsen, Line Præst; Laustsen, Andreas Hougaard; Lomonte, Bruno; Gutiérrez, José María (2017-01-06)
A toxicovenomic analysis of the venomof the forest cobra, N. melanoleuca,was performed, revealing the presence of a total of 52 proteins by proteomics analysis. The most abundant proteins belong to the three-finger ...
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High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays 

Engmark, Mikael Gerling; Andersen, Mikael Rørdam; Laustsen, Andreas Hougaard; Patel, Jigar; Sullivan, Eric; de Masi, Federico; Hansen, Christian S.; Kringelum, Jens V.; Lomonte, Bruno; Gutiérrez, José María; Lund, Ole (2016-11-08)
Snakebite envenoming is a serious condition requiring medical attention and administration of antivenom. Current antivenoms are antibody preparations obtained from the plasma of animals immunised with whole venom(s) and ...

From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy 

Laustsen, Andreas Hougaard; Engmark, Mikael Gerling; Milbo, Christina; Johannesen, Jonás; Lomonte, Bruno; Gutiérrez, José María; Lohse, Brian (2016)
The snake is the symbol of medicine due to its association with Asclepius, the Greek God of medicine, and so with good reasons. More than 725 species of venomous snakes have toxins specifically evolved to exert potent ...
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Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping 

Engmark, Mikael Gerling; Lomonte, Bruno; Gutiérrez, José María; Laustsen, Andreas Hougaard; de Masi, Federico; Andersen, Mikael Rørdam; Lund, Ole (2017-07)
Snakebite antivenom is a 120 years old invention based on polyclonal mixtures of antibodies purified from the blood of hyper-immunized animals. Knowledge on antibody recognition sites (epitopes) on snake venom proteins ...
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Gutiérrez, José María (12)
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Engmark, Mikael Gerling (7)Lohse, Brian (5)Andersen, Mikael Rørdam (3)de Masi, Federico (2)Fernández Ulate, Julián (2)Knudsen, Cecilie (2)Lauridsen, Line Præst (2)... View MoreTypeartículo científico (12)ProcedenceVicerrectoría de Investigación (12)Vicerrectoría de Docencia (3)... View MoreHas File(s)Yes (12)

  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
  • Biblioteca Digital Carlos Melendez (CIHAC)
  • Repositorio de Fotografías
  • Colección de videos de UPA-VAS
  • Sitios recomendados

  • Buscador regional de LA Referencia
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  • Scientific Electronic Library Online (SciELO)
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  • Redalyc
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  • @Ciencia_UCR
  • Sobre Kérwá
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Contact Us | Send Feedback
Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.