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Mostrando ítems 948-967 de 1169
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Role of cyclooxygenases in oedema-forming activity of bothropic venoms
(2007-04)The venoms of Bothrops asper (BaV) and Bothrops jararaca (BjV), two of the most medically important poisonous snakes of Latin America, cause pronounced oedema in the victims through poorly understood mechanisms. In the ... -
Role of enzymatic activity inmuscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?
(Peer Journal 2:e569; DOI 10.7717/peerj.569, 2014-09-16)Viperid venoms often contain mixtures of Asp49 and Lys49 PLA2 myotoxin isoforms, relevant to development of myonecrosis. Given their difference in catalytic activity, mechanistic studies on each type require highly ... -
Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice
(2006)Objective To assess the role of nitric oxide in the most relevant local and systemic manifestations in mice injected with the venom of the snake Bothrops asper. Mice were pretreated with nitric oxide synthase inhibitors, ... -
Role of the animal model on the pharmacokinetics of equine-derived antivenoms
(2013-08)Antivenom pharmacokinetics has been studied in heterologous models in which the animal species used as immunoglobulin source is different from that used as recipient. In these models, after intravenous administration of ... -
Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: In vitro and in vivo gene expression analysis of the effects of the toxin
(2005-09)To assess the indirect effects of snake venom metalloproteinases (SVMP) on host tissue local necrosis, we investigated the effect of the SVMP jararhagin on the gene expression profiles of human fibroblasts in vitro and ... -
Role of TNF-α, IL-1β and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice
(2005-02)The role of the cytokines TNF-α, IL-1β and IL-6 in the acute local pathological effects induced by Bothrops asper snake venom was assessed in mice. Intramuscular injection of this venom induced increments in IL-1β and IL-6 ... -
Rotavirus en un servicio de neonatología: descripción de una epidemia
(Revista Médica del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera: (2): 159-172, 1980)Durante una epidemia por rotavirus comprobada en la comunidad, se estudió la situación de los recién nacidos en un Servicio de Neonatología, demostrándose la ocurrencia de tres brotes consecutivos en un período de 10 ... -
Rotavirus y campylobacter fetus jejuni asociados a un brote de diarrea en terneros
(Revista de Biología Tropical 32 (2) 303-304, 1984-04-27)Rotaviruses and Campylobacter fetus jejuni are ubiquitous agents of diarrheal disease in animals and humans. Under natural conditions they do not seem to cross inter-species barriers; a zoonosis has not been documented for ... -
S-IgA cholera toxin and rotavirus antibody in human colostrum
(Acta Paediar Scand 68(3): 161-164. 1979, 1979)S-IgA cholera toxin and rotavirus antibody inhuman colostrum. Acta Paediatr Scand, 68: 161, 1979.—S-1gA antibodies against cholera toxin and rotavirus were assayed in 43 colostral samples by means of an enzyme-linked ... -
Salt/Sodium Intake Estimation in children and adolescents of Costa Rica
(2020)The objectives of this study were to estimate sodium intake and to identify the main dietary sources of this nutrient in young people. Cross-sectional study performed in 2685 students from 64 schools and high-schools of ... -
SARS-CoV-2 genomic surveillance in Costa Rica: Evidence of a divergent population and an increased detection of a spike T1117I mutation
(2021)Genome sequencing is a key strategy in the surveillance of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. Latin America is the hardest-hit region of the world, accumulating almost 20% of COVID-19 cases ... -
Scarce detection of mobile erm genes associated with tetQ in Bacteroides and Parabacteroides from Costa Rica
(2013-06)The frequency of finding of clindamycin-resistant anaerobic bacteria in clinical samples has doubled from 2008 to 2010 in Costa Rica. To determine whether this increase is due to dissemination of erm genes aided by tetQ ... -
Screening for target toxins of the antiophidic protein DM64 through a gel-based interactomics approach
(2017-01)DM64 is a glycosylated protein with antivenomactivity isolated fromthe serum of the opossumDidelphis aurita. It binds non-covalently to myotoxins I (Asp49) and II (Lys49) from Bothrops asper venom and inhibits their myotoxic ... -
SDS‑induced hexameric oligomerization of myotoxin‑II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance
(2023)We report the solution behavior, oligomerization state, and structural details of myotoxin-II purified from the venom of Bothrops asper in the presence and absence of sodium dodecyl sulfate (SDS) and multiple lipids, as ... -
Seasonal profiles of Aedes aegypti (Diptera: Culicidae) larval habitats in an urban area of Costa Rica with a history of mosquito control
(2008-06-01)Dengue is the most important arboviral disease worldwide and the principal vector-borne disease in Costa Rica. Control of Aedes aegypti populations through source reduction is still considered the most effective way of ... -
Seasonal wetlands in the Pacific coast of Costa Rica and Nicaragua: environmental characterisation and conservation status
(2015)On the Pacific coast of Nicaragua and Costa Rica, rainfall patterns and clay-rich soils allow the development of extensive wetlands. These environments constitute unique habitats for the maintenance of aquatic biodiversity ... -
Second generation snake antivenomics: Comparing immunoaffinity and immunodepletion protocols
(2012-09-15)A second generation antivenomics protocol, based on affinity chromatography, was compared with a previously (first generation) immunodepletion protocol using as a proof of principle the pan-African EchiTAb-Plus-ICP® IgG ... -
Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases
(2008-09-01)The effects of myotoxin III (MT-III), a phospholipase A2 (sPLA2) from Bothrops asper snake venom, and crotoxin B (CB), a neurotoxic and myotoxic sPLA2 from the venom of Crotalus durissus terrificus, on cyclooxygenases ... -
Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score
(2015-09-15)For more than 100 years, antivenoms have been produced by traditional methods of immunization of large mammals with mixtures of snake venoms (World Health Organization, 2010 and Gutiérrez et al., 2011). With the introduction ... -
Senses the Intracellular Environment through the BvrR/BvrS Two-Component System, Which Allows To Adapt to Its Replicative Niche
(2018-03-22)Brucella abortus is a facultative extracellular-intracellular pathogen belonging to a group of Alphaproteobacteria that establishes close interactions with animal cells. This bacterium enters host cells in a membrane-bound ...