Listar Microbiología por título
Mostrando ítems 644-663 de 1169
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Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle
(2005)Phospholipases A2 (PLA2) are important constituents of snake venoms, being responsible for several of their toxic actions. Extracts from plants used in folk medicine were screened for inhibition of the enzymatic activity ... -
Innovative immunization strategies for antivenom development
(2018)Snakes, scorpions, and spiders are venomous animals that pose a threat to human health, and severe envenomings from the bites or stings of these animals must be treated with antivenom. Current antivenoms are based on ... -
Insights into the mutation T1117I in the spike and the lineage B.1.1.389 of SARS-CoV-2 circulating in Costa Rica
(2022-06)Emerging mutations and genotypes of the SARS-CoV-2 virus, responsible for the COVID-19 pandemic, have been reported globally. In Costa Rica during the year 2020, a predominant genotype carrying the mutation T1117I in the ... -
Instituto Clodomiro Picado: Ciencia y Tecnología Endógenas en la Solución de un Problema de la Salud Pública en Centroamérica
(1999-05)El accidente ofídico re-presenta un importante problema de salud pública en Centroamérica. En Costa Rica, por ejemplo, ocurren alrededor de 600 mordeduras por serpientes en humanos anualmente (Gutiérrez, 1995), en tanto ... -
Insulin resistance and impaired glucose tolerance in overweight and obese Costa Rican schoolchildren
(2008)Background. Worldwide obesity has become an unprecedented public health challenge. In addition, a notable increase in the risk of insulin resistance and type 2 diabetes mellitus has emerged. In Costa Rica, there are no ... -
Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus
(2013)Background Understanding the processes that drive the evolution of snake venom is a topic of great research interest in molecular and evolutionary toxinology. Recent studies suggest that ontogenetic changes in venom ... -
Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: proteome, toxicity, and cross-neutralization by antivenom
(2016-03)In Colombia, nearly 2.8% of the 4200 snakebite accidents recorded annually are inflicted by coral snakes (genus Micrurus). Micrurus dumerilii has a broad distribution in this country, especially in densely populated ... -
Interacciones celulares en el proceso de invasión de Shigella sp
(Rev Panam Infectol 2009;11(2):56-61, 2009)Shigella, como agente etiológico de la disentería bacilar, es un problema importante de salud pública a nivel mundial. Para el establecimiento de la infección este microorganismo emplea las funciones celulares y de ... -
Interacción de neutrófilos murinos con Brucella abortus
(2019-12)La brucelosis es una enfermedad zoonótica con distribución mundial. La enfermedad se caracteriza por ocasionar fiebre ondulante en humanos y abortos en animales domésticos como vacas, ovejas, cabras, cerdos y perros. ... -
Interferencia en la cuantificación de electrolitos al emplear tubos con gel separador
(2020-12-15)Los tubos con gel separador para suero sanguíneo se utilizan ampliamente para recolectar, transportar y almacenar muestras de sangre con el fin de realizar ensayos de Química Clínica. Se plantea la necesidad de verificar ... -
Intervenciones terapéuticas en población obesa: Efecto sobre la inflamación
(2021)Actualmente la obesidad es considerada una pandemia y una de las enfermedades no transmisibles más importantes a nivel mundial. Durante las últimas dos décadas, investigaciones han revelado una relación estrecha entre el ... -
Intracellular passage triggers a molecular response in that increases its infectiousness
(2021)Brucella abortus is a facultative extracellular-intracellular pathogen that encounters a diversity of environments within the host cell. We report that bacteria extracted from infected cells at late stages (48 h post-infection) ... -
Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: comparison between Fab and IgG
(2003-02)The efficacy of intramuscular (im) administration of sheep Fab and IgG antivenoms was assessed in a mouse experimental model of envenomation by Bothrops asper, in order to test if the more rapid absorption of Fab improves ... -
Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: Different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies
(2013-07)The composition and toxicological profile of the venom of the rattlesnake Crotalus simus in Mexico was analyzed at the subspecies and individual levels. Venoms of the subspecies C. s. simus, C. s. culminatus and C. s. ... -
Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: functional profile of hemolytic and non-hemolytic isoforms
(2018-04)A unique feature of the venom of Micrurus fulvius (Eastern coral snake) is its ability to induce severe intravascular hemolysis in particular species, such as dogs or mice. This effect was previously shown to be induced ... -
Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: Identification of directly hemolytic phospholipases A2
(Toxicon 90, 2014)Intravascular hemolysis has been described in envenomings by the Eastern coral snake, Micrurus fulvius, in dogs. An experimental model of intravascular hemolysis was developed in mice after intravenous (i.v.) injection ... -
Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows
(2010-11)Administration of antivenoms to treat snakebite envenomings has the potential risk of inducing early adverse reactions. The mechanisms involved in these reactions are unclear. In this study, polyspecific antivenom consisting ... -
Isolates of Clostridium perfringens recovered from Costa Rican patients with antibiotic-associated diarrhoea are mostly enterotoxin-negative and susceptible to first-choice antimicrobials
(2008-03)To assess the prevalence of enterotoxigenic Clostridium perfringens among adults suffering from antibiotic-associated diarrhoea in a Costa Rican hospital, faecal samples were analysed from 104 patients by a cultivation ... -
Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom
(2012-12-01)The aim of this study was the isolation of the LAAO from Lachesis muta venom (LmLAAO) and its biochemical, functional and structural characterization. Two different purification protocols were developed and both provided ...