Listar Microbiología por título
Mostrando ítems 571-590 de 1169
-
Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
(2019)Antivenoms are fundamental in the therapy for snakebites. In elapid venoms, there are toxins, e.g. short-chain α-neurotoxins, which are quite abundant, highly toxic, and consequently play a major role in envenomation ... -
Host response to Bothrops asper snake venom: analysis of edema formation, inflammatory cells, and cytokine release in a mouse model
(1993)As part of tle characterization of the host reactivity to the venom of Bothrops asper, we investigated the inflammatory responses in the mouse footpad model. The subcutaneously iniected venom induced a rapid increase of ... -
Host-Feeding Patterns of the Mosquito Assemblage at Lomas Barbudal Biological Reserve, Guanacaste, Costa Rica
(2021-07)Mosquito-borne pathogens have spread throughout tropical regions of the Western Hemisphere causing increased burden of disease in the region. Outbreaks of dengue fever, yellow fever, chikungunya, West Nile, and Zika have ... -
Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III
(2014-05-15)Human cytomegalovirus (HCMV) establishes lifelong infection with recurrent episodes of virus production and shedding despite the presence of adaptive immunological memory responses including HCMV immune immunoglobulin G ... -
Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration
(2008)The presence of human heterophilic antibodies against horse immunoglobulins (HHA-HI) was determined by ELISA in sera from healthy volunteers and from patients who received equine antivenom for therapy of snake bite ... -
Hybrid mathematical modeling decodes the complexity of sphingolipid pathway to predict chemosensitivity
(2017)Sphingolipid (SL) signaling pathway is a complex biological system able to integrate different types of cellular stress signals related to induction of cell death pathways with special interest in cancer. This makes of ... -
Hydrocarbon Degrading Microflora in a Tropical fuel-Contaminated Aquifer: Assessing the Feasibility of PAH Bioremediation
(2012-01)An aquifer located within a petroleum processing plant in Moín, Costa Rica, suffers hydrocarbon pollution. This study aimed to determine the ability of indigenous microorganisms from this site to degrade polycyclic ... -
Hydrology Affects Environmental and Spatial Structuring of Microalgal Metacommunities in Tropical Pacific Coast Wetlands
(2016-02-22)The alternating climate between wet and dry periods has important effects on the hydrology and therefore on niche-based processes of water bodies in tropical areas. Additionally, assemblages of microorganism can show spatial ... -
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants
(2003-05)The ability of Lys49 and Asp49 phospholipases A2 (PLA2), from Bothrops asper snake venom, to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of both toxins (5–20 μg/paw) ... -
Identificación de especies causantes de Leishmaniosis cutánea en Costa Rica por la técnica de Polimorfismos en la Longitud de Fragmentos de Restricción (RFLP) a partir del gen de la proteína HSP 70
(2021)La leishmaniosis es un complejo de enfermedades causada por protozoarios del género Leishmania y transmitida por insectos hematófagos del género Phlebotomus y Lutzomyia,. Puede presentar distintas manifestaciones clínicas, ... -
Identificación de moléculas inmunorreguladoras inducidas por la bacteria Helicobacter pylori en modelos in vitro e in vivo
(2023)El cáncer gástrico (CG) es el cuarto tipo de cáncer más mortal a nivel mundial, principalmente por su detección tardía y la falta de terapias eficaces. La inmunoterapia ha mostrado ser muy prometedora en el tratamiento del ... -
Identification of cancer chemosensitivity by ODE and GMM modeling of heterogeneous cellular response to perturbations in fluorescent sphingolipid metabolism
(2016-11-11)Cancer refers to a group of diseases in which cells display uncontrolled growth. Chemotherapy options are usually conditioned by generating resistance which is explained in part by the intrinsic heterogeneity of the ... -
Identification of linear B-cell epitopes on myotoxin-II, a Lys49 phospholipase A2 homologue from Bothrops asper snake venom
(2012)Knowledge on toxin immunogenicity at the molecular level can provide valuable information for the improvement of antivenoms, as well as for understanding toxin structure– function relationships. The aims of this study ... -
Identification of New Snake Venom Metalloproteinase Inhibitors Using Compound Screening and Rational Peptide Design
(2012)The majority of snakebite envenomations in Central America are caused by the viperid species Bothrops asper, whose venom contains a high proportion of zinc-dependent metalloproteinases that play a relevant role in the ... -
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene
(2000-08)Clostridium perfringens phospholipase C (PLC), also called α-toxin, is the major virulence factor in the pathogenesis of gas gangrene. The toxic activities of genetically engineered α-toxin variants harboring single ... -
Identification of the myotoxic site of the Lys49 phospholipase A2 from Agkistrodon piscivorus piscivorus snake venom: synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities
(2001)Group II phospholipase A2 (PLA2) myotoxins found in the venoms of Crotalidae snakes can be divided into `Asp49' and `Lys49' isoforms, the latter being considered catalytically-inactive variants. Previous studies on one ... -
Immune Response Towards Snake Venoms
(2011)The immune response involves a complex repertoire of innate and adaptive responses to foreign agents in the organism. The present review focuses on the immune response to snake venoms, including those occurring in snakebite ... -
Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom
(2010-11)BaP1 is a P-I class of Snake Venom Metalloproteinase (SVMP) relevant in the local tissue damage associated with envenomations by Bothrops asper, a medically-important species in Central America and parts of South America. ... -
Immunochemical characterization and role in toxic activities of region 115-129 of myotoxin II, a Lys49 phospholipase A2 from Bothrops asper snake venom
(1998-10)The region 115–129 of myotoxin II, a catalytically inactive Lys49 phospholipase A2, was previously shown to constitute a heparin-binding site and to be involved in its cytolytic action in vitro. An immunochemical ...