• Efficacy of IgG and F(ab′)2 Antivenoms to Neutralize Snake Venom-induced Local Tissue Damage as Assessed by the Proteomic Analysis of Wound Exudate 

      Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Shannon, John D.; Ayala Castro, Carla N.; Villalta Arrieta, Mauren; Gutiérrez, José María; Fox, Jay W. (2012)
      Proteomic analysis of wound exudates represents a valuable tool to investigate tissue pathology and to assess the therapeutic success of various interventions. In this study, the ability of horse-derived IgG and F(ab0)2 ...
    • Elaboración de un plan piloto para la implementación de un modelo de gestión de calidad basado en procesos en la sede de Santa Ana del Hospital Clínica Bíblica 

      Vargas Valerio, Sofía (2023-07-25)
      El presente trabajo pretende la creación de un plan piloto en formato DMAIC para la migración del Sistema de Gestión de Calidad actual a un sistema de gestión basado en procesos en el Laboratorio Clínico de la sede de Santa ...
    • Elapid venom toxins: multiple recruitments of ancient scaffolds 

      Alape Girón, Alberto; Persson, Bengt; Cederlund, Ella; Flores Díaz, Marietta; Gutiérrez, José María; Thelestam, Mónica; Bergman, Tomas; Jörnvall, Hans (1999-01)
      Nigroxins A and B, two myotoxic phospholipases A2 (PLA2s) from the venom of the American elapid Micrurus nigrocinctus, belong to a new PLA2 subclass. Their primary structures were established and compared with those of ...
    • Electrophoretic and immunochemical studies of Micrurus venoms 

      Alape Girón, Alberto; Lomonte, Bruno; Gustafsson, Bjorn; Da Silva, Nelson Jorge; Thelestam, Mónica (1994)
      The electrophoretic mobilities of venom components from 15 Micrurus species were studied by polyacrylamide gel electrophoresis. The venoms showed species-specific protein patterns under native (PAGE) or denaturing (urea-PAGE) ...
    • Elimination of fungicides in biopurification systems: Effect of fungal bioaugmentation on removal performance and microbial community structure 

      Murillo Zamora, Sergio; Castro Gutiérrez, Víctor Manuel; Masís Mora, Mario Alberto; Lizano Fallas, Verónica; Rodríguez Rodríguez, Carlos E. (2017-11)
      Bioaugmentation with ligninolytic fungi represents a potential way to improve the performance of biomixtures used in biopurification systems for the treatment of pesticide-containing agricultural wastewater. The fungus ...
    • Elucidating Spirocerca lupi spread in the Americas by using phylogenetic and phylogeographic analyses 

      Alfaro Segura, Paula; Robleto Quesada, Joby; Montenegro Hidalgo, Víctor M.; Molina Mora, José Arturo; Baneth, Gad; Verocai, Guilherme G.; Rodríguez Vivas, Roger I.; Rojas Araya, Alicia (2023)
      Spirocerca lupi is a parasitic nematode of domestic and wild canids of the world. This nematode induces esophageal spirocercosis and may eventually lead to carcinomas, aortic aneurisms, and death of the animal. Two genotypes ...
    • Emergence of an Outbreak-Associated Clostridium difficile Variant with Increased Virulence 

      Quesada Gómez, Carlos; López Ureña, Diana; Chaves Olarte, Esteban; Acuña Amador, Luis Alberto; Villalobos Zúñiga, Manuel Antonio; Du, Tim; Freire, Rosemayre; Guzmán Verri, Caterina; Gamboa Coronado, María del Mar; Lawley, Trevor D.; Moreno Robles, Edgardo; Mulvey, Michael R.; de Castro Brito, Gerly Anne; Rodríguez Cavallini, Evelyn; Rodríguez Sánchez, César (2015-04)
      The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican ...
    • Emergence of Clostridium difficile NAP1 in Latin America 

      Quesada Gómez, Carlos; Rodríguez Sánchez, César; Gamboa Coronado, María del Mar; Rodríguez Cavallini, Evelyn; Du, Tim; Mulvey, Michael R.; Villalobos Zúñiga, Manuel Antonio; Boza Cordero, Ricardo (2010-02)
      The NAP1 and NAP2 strains of Clostridium difficile have been linked to nosocomial outbreaks of antibiotic-associated diarrhea (AAD) and pseudomembranous colitis in North American and European countries (4, 5). We found ...
    • Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa 

      Williams, David J.; Gutiérrez, José María; Calvete Chornet, Juan José; Wüster, Wolfgang; Ratanabanangkoon, Kavi; Paiva, Owen K.; Brown, Nicholas I.; Casewell, Nicholas R.; Harrison, Robert A.; Rowley, Paul D.; O'Shea, Mark; Jensen, Simon D.; Winkel, Kenneth D.; Warrell, David A. (2011-08-24)
      The development of snake antivenoms more than a century ago should have heralded effective treatment of the scourge of snakebite envenoming in impoverished, mostly rural populations around the world. That snakebite still ...
    • Enfermedad de Chagas en Costa Rica: Estudio comparativo en dos épocas diferentes 

      Chinchilla Carmona, Misael; Castro Castillo, Alfredo; Reyes Lizano, Liliana; Guerrero Bermúdez, Olga Marta; Calderón Arguedas, Ólger; Troyo Rodríguez, Adriana (2006)
      Para actualizar la situación de la Enfermedad de Chagas en Costa Rica se realizó un estudio serológico y epidemiológico parcial en 4 zonas de riesgo en el país. Un total de 1.561 estudiantes de 6 a 12 años fueron estudiados ...
    • Enfermedades causadas por Xylella fastidiosa en Estados Unidos y Costa Rica 

      de la Fuente, Leonardo; Chacón Díaz, Carlos; Almeida, Rodrigo P. P. (2017)
      El texto habla sobre Estados Unidos y su historia en relación a las enfermedades causadas por la bacteria Xylella fastidiosa. Se mencionan los primeros registros de estas enfermedades en la década de 1880 y cómo se descubrió ...
    • ENSO‐Influenced Drought Drives Methane Flux Dynamics in a Tropical Wet Forest Soil 

      Aronson, Emma L.; Dierick, Diego; Botthoff, J. K.; Oberbauer, Steven F.; Zelikova, Tamara Jane; Harmon, Thomas C.; Rundel, Philip W.; Johnson, Robert F.; Swanson, Amanda C.; Pinto Tomás, Adrián A.; Artavia León, Allan; Matarrita Carranza, Bernal; Allen, Michael F. (2019)
      Global atmospheric methane growth rates have wildly fluctuated over the past three decades, which may be driven by the proportion of tropical land surface saturated by water. The El Niño/Southern Oscillation Event (ENSO) ...
    • Enteritis y colitis infecciosa del hombre 

      Mata Jiménez, Leonardo; Simhon Edgar, Alberto (Adel Microbiol Enf Infecc 1(1), 1982)
      Most diarrheas affecting man in developing nations have an: infectious origin, and are transmitted from person to person or indirectly thorough water, food and utensils contaminated with the agents. About two thirds of ...
    • Enterococci as a key parameter for water quality index: Purires River, Costa Rica 

      Chacón Jiménez, Luz María; Arias Mora, Víctor; Barrantes Jiménez, Kenia; Beita Sandí, Wilson; Reyes Lizano, Liliana; Achí Araya, María Rosario (2018)
      This study used the Canadian Water Quality Index (CWI) to characterize water sampled at three points within the Purires River micro basin, Costa Rica. The first sampling point is located in a high zone with domestic ...
    • Envenamiento por mordedura de serpiente en Costa Rica en 1996: Epidemiología y consideraciones clínicas 

      Arroyo Gutiérrez, Olga; Rojas Céspedes, Gustavo; Gutiérrez, José María (1999-12)
      El presente trabajo se efectúa para tener una visión actualizada y completa de las principales características epidemiológicas del envenenamiento por mordedura de serpiente en Costa Rica. Asimismo, se incluyen algunas ...
    • Envenenamientos por mordeduras de serpientes en América Latina y el Caribe: Una visión integral de carácter regional 

      Gutiérrez, José María (2011-01)
      Se analiza la situación de los envenenamientos por mordeduras de serpiente en América Latina y el Caribe, los cuales representan un importante problema de Salud Pública en la región. Esta patología afecta, fundamentalmente, ...
    • Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins 

      Zornetta, Irene; Caccin, Paola; Fernández Ulate, Julián; Lomonte, Bruno; Gutiérrez, José María; Montecucco, Cesare (PLoS Negl Trop Dis 6(2): e1526, 2012-02-21)
      Skeletal muscle necrosis is a common manifestation of viperid snakebite envenomations. Venoms from snakes of the genus Bothrops, such as that of B. asper, induce muscle tissue damage at the site of venom injection, provoking ...
    • Enzymatic labelling of venom phospholipase A2 toxins 

      Spolaore, Barbara; Fernández Ulate, Julián; Lomonte, Bruno; Massimino, Maria Lina; Tonello, Fiorella (2019)
      Almost all animal venoms contain secretory phospholipases A2 (PLA2s), 14 kDa disulfide-rich enzymes that hydrolyze membrane phospholipids at the sn-2 position, releasing lysophospholipids and fatty acids. These proteins, ...
    • Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia 

      Quintero Vélez, Juan Carlos; Aguirre Acevedo, Daniel Camilo; Rodas González, Juan David; Arboleda, Margarita; Troyo Rodríguez, Adriana; Vega Aguilar, Francisco; Osorio Quintero, Lisardo; Rojas Arbeláez, Carlos (2018-10-31)
      Introduction Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although ...