Listar Microbiología por título

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    • Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase 

      Gutiérrez, José María; Núñez, Javier; Escalante Muñoz, Teresa; Rucavado Romero, Alexandra (2006-01)
      The effects of blood flow interruption on the ultrastructural alterations induced by a snake venom hemorrhagic metalloproteinase on skeletal muscle capillary endothelial cells were studied. Saline solution or the ...

    • Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo 

      Zamunér, Stella Regina; Gutiérrez, José María; Muscará, Marcelo N.; Teixeira, Simone A.; Teixeira, Catarina de Fátima (2001-10)
      Venoms from snakes of the genus Bothrops cause pronounced local effects in the victims. These alterations result not only from the direct toxic action of venom components, but also from the prominent inflammatory reaction ...

    • Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy 

      Escalante Muñoz, Teresa; Rucavado Romero, Alexandra; Kamiguti, Aura S.; Theakston, R. David G.; Gutiérrez, José María (2004-02)
      The ability of the P-I metalloproteinase BaP1, isolated from the venom of the snake Bothrops asper, to induce systemic bleeding, thrombocytopenia and defibrinogenation was assessed in an experimental mouse model. Intravenous ...

    • Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment 

      Farsky, Sandra H. P.; Gonçalves, Luís Roberto de Camargo; Gutiérrez, José María; Correa, Adriana P.; Rucavado Romero, Alexandra; Gasque, Philippe; Tambourgi, Denise V. (2000)
      The venom of the snake Bothrops asper, the most important poisonous snake in Central America, evokes an inflammatory response, the mechanisms of which are not well characterized. The objectives of this study were to ...

    • Bothrops asper: Beauty and peril in the Neotropics 

      Gutiérrez, José María (2009-12-01)
      Snakes have inspired fascination and fear to humans since ancient times, as reflected by the common presence of these reptiles in the mythology of many civilizations. Such sense of awe has been associated to the impact ...

    • Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain 

      Cintra Francischinelli, Mariana; Caccin, Paola; Chiavegato, Angela; Pizzo, Paola; Carmignoto, Giorgio; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Montecucco, Cesare (2010-07-26)
      Myotoxins play a major role in the pathogenesis of the envenomations caused by snake bites in large parts of the world where this is a very relevant public health problem. We show here that two myotoxins that are major ...

    • Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of Bothrops asper snake venom 

      Lomonte, Bruno; Tarkowski, Andrej; Hanson, Lars Ake (1994)
      The cytotoxic activity of Bothrops asper myotoxin II, a lysine-49 phospholipase A2 isoform, on different cell types in culture, was investigated. Myotoxin II caused a dose-dependent cytolytic effect on all cell types tested, ...

    • Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide 

      Barquero Calvo, Elías; Mora Cartín, Ricardo; Arce Gorvel, Vilma; de Diego, Juana L.; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Buret, Andre G.; Gorvel, Jean Pierre; Moreno Robles, Edgardo (2015-05-06)
      Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs), enhance their microbicidal function, and promote the survival of these leukocytes for protracted periods of time. Brucella abortus ...

    • Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains 

      Suárez Esquivel, Marcela; Ruiz Villalobos, Nazareth; Castillo Zeledón, Amanda; Jiménez Rojas, César; Martin Roop II, Roy; Comerci, Diego J.; Barquero Calvo, Elías; Chacón Díaz, Carlos; Caswell, Clayton C.; Baker, Kate S.; Chaves Olarte, Esteban; Thomson, Nicholas R.; Moreno Robles, Edgardo; Letesson, Jean J.; De Bolle, Xavier; Guzmán Verri, Caterina (2016-09-29)
      Brucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research ...

    • Brucella canis Is an Intracellular Pathogen That Induces a Lower Proinflammatory Response than Smooth Zoonotic Counterparts 

      Chacón Díaz, Carlos; Altamirano Silva, Pamela; González Espinoza, Gabriela; Medina, María Concepción; Alfaro Alarcón, Alejandro; Bouza Mora, Laura; Jiménez Rojas, César; Wong Araya, Melissa; Barquero Calvo, Elías; Rojas Campos, Norman; Guzmán Verri, Caterina; Moreno Robles, Edgardo; Chaves Olarte, Esteban (2015-11-10)
      Canine brucellosis caused by Brucella canis is a disease of dogs and a zoonotic risk. B. canis harbors most of the virulence determinants defined for the genus, but its pathogenic strategy remains unclear since it has not ...

    • Brucella Genetic Variability in Wildlife Marine Mammals Populations Relates to Host Preference and Ocean Distribution 

      Suárez Esquivel, Marcela; Baker, Kate S.; Ruiz Villalobos, Nazareth; Hernández Mora, Gabriela; Barquero Calvo, Elías; Castillo Zeledón, Amanda; Jiménez Rojas, César; Chacón Díaz, Carlos; Cloeckaert, Axel; Chaves Olarte, Esteban; Thomson, Nicholas R.; Moreno Robles, Edgardo; Guzmán Verri, Caterina; González Barrientos, Rocío (2017)
      Intracellular bacterial pathogens probably arose when their ancestor adapted from a free-living environment to an intracellular one, leading to clonal bacteria with smaller genomes and less sources of genetic plasticity. ...

    • Brucella neotomae Infection in Humans, Costa Rica 

      Suárez Esquivel, Marcela; Ruiz Villalobos, Nazareth; Jiménez Rojas, César; Barquero Calvo, Elías; Chacón Díaz, Carlos; Víquez Ruiz, Eunice; Rojas Campos, Norman; Baker, Kate S.; Oviedo Sánchez, Gerardo; Amuy, Ernesto; Chaves Olarte, Esteban; Thomson, Nicholas R.; Moreno Robles, Edgardo; Guzmán Verri, Caterina (2017-06)
      Several species of Brucella are known to be zoonotic, but B. neotomae infection has been thought to be limited to wood rats. In 2008 and 2011, however, B. neotomae was isolated from cerebrospinal fluid of 2 men with ...

    • Brucellosis caused by the wood rat pathogen Brucella neotomae: two case reports 

      Villalobos Vindas, Juan M.; Amuy, Ernesto; Barquero Calvo, Elías; Rojas Campos, Norman; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Moreno Robles, Edgardo (2017-12-19)
      Background: Brucellosis is a chronic bacterial disease caused by members of the genus Brucella. Among the classical species stands Brucella neotomae, until now, a pathogen limited to wood rats. However, we have identified two ...

    • Brucellosis in mammals of Costa Rica: An epidemiological survey 

      Hernández Mora, Gabriela; Bonilla Montoya, Roberto; Barrantes Granados, Osvaldo; Esquivel Suárez, Andrea; Montero Caballero, Danilo; González Barrientos, Rocío; Fallas Monge, Zeanne; Palacios Alfaro, José David; Baldi Salas, Mario; Campos Chacón, Elena; Chanto Chacón, Grettel; Barquero Calvo, Elías; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Romero Zúñiga, Juan José; Moreno Robles, Edgardo (2017-08-09)
      Brucellosis has been an endemic disease of cattle and humans in Costa Rica since the beginning of XX century. However, brucellosis in sheep, goats, pigs, water buffaloes, horses and cetaceans, has not been reported in the ...

    • Butanol production by Clostridium beijerinckii BA101 using cassava flour as fermentation substrate: enzymatic versus chemical pretreatments 

      Lépiz Aguilar, Leonardo; Rodríguez Rodríguez, Carlos E.; Arias Echandi, María Laura; Lutz Cruz, Giselle; Ulate Padgett, William (2011)
      Cassava flour (CF), a cost-effective source of starch, was employed as a substrate for successful acetone butanol-ethanol (ABE) production by batch-fermentation with Clostridium beijerinckii. The effect of temperature, initial ...

    • Búsqueda de terapias antimicrobianas alternativas: potencial antimicrobiano del veneno de serpientes 

      Arce Bejarano, Ruth (2021)
      La resistencia a los antimicrobianos genera una inminente crisis de salud pública que amenaza con aumentar en los próximos años. Desde hace varias décadas organismos internacionales se han preocupado por llamar la atención ...

    • Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors 

      Cintra Francischinelli, Mariana; Pizzo, Paola; Rodrigues Simioni, Lea; Ponce Soto, Luis Alberto; Rossetto, O.; Lomonte, Bruno; Gutiérrez, José María; Pozzan, T.; Montecucco, Cesare (2009-04-17)
      Snake myotoxins have a great impact on human health worldwide. Most of them adopt a phospholipase A2 fold and occur in two forms which often co-exist in the same venom: the Asp49 toxins hydrolyse phospholipids, whilst Lys49 ...

    • Calcium ion independent membrane leakage induced by phospholipase-like myotoxins 

      Rufini, Stefano; Cesaroni, P.; Desideri, A.; Farias, R.; Gubensek, F.; Gutiérrez, José María; Luly, P.; Massoud, R.; Morero, R.; Pedersen, J. Z. (1992-12)
      The two snake venom myotoxins ammodytin L and myotoxin II, purified respectively from Vipera ammodytes ammodytes and Bothrops asper, have phospholipase-like structures but lack an Asp-49 in the active site and are without ...

    • Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A2 homologue on a lymphoblastoid cell line 

      Mora Rodríguez, Rodrigo Antonio; Maldonado, Alexis; Valverde Rojas, Berta E.; Gutiérrez, José María (2006-01)
      A catalytically-inactive Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper induces diverse effects (necrosis, apoptosis and proliferation) in a lymphoblastoid cell line, depending on the toxin ...

    • Calidad bacteriológica y desechos sólidos en cinco ambientes costeros de Costa Rica 

      García Cortés, Vera; Acuña González, Jenaro; Vargas Zamora, José A.; García Céspedes, Jairo (2006-09-01)
      Anthropogenic waste and water bacteriological quality were surveyed twice a year in 2000 and in 2002 at five coastal marine environments in Costa Rica, one in the Caribbean (Moín Bay) and four in the Pacific (Culebra ...