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dc.creatorAlpízar Alpízar, Warner
dc.creatorPérez Pérez, Guillermo Ignacio
dc.creatorUne, Clas Allan
dc.creatorCuenca Berger, Patricia
dc.creatorSierra Ramos, Rafaela
dc.date.accessioned2015-07-24T21:41:30Z
dc.date.available2015-07-24T21:41:30Z
dc.date.issued2005-09-13
dc.identifier.citationhttp://link.springer.com/article/10.1007/s10238-005-0082-3
dc.identifier.issn1591-8890
dc.identifier.issn1591-9528
dc.identifier.urihttps://hdl.handle.net/10669/15117
dc.descriptionArtículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 2005. Este documento es privado debido a limitaciones de derechos de autor.es_ES
dc.description.abstractSeveral risk factors have been associated with gastric cancer, among them Helicobacter pylori infection. This bacterium yields inflammation, the degree of which depends on the bacterial strain and the severity of the host response. The inflammatory response involves a complex cytokine network. Recently, polymorphisms of the genes coding for interleukin-113 (IL-1B), interleukin-lRa (ILRN) and interleukin-10 have been associated with an increased risk of gastric cancer. In order to determine the association of the IL-1B, IL-1RN and IL-10 polymorphisms with gastric cancer in a high-risk Costa Rican population, we analysed purified DNA of 58 gastric cancer patients, 99 controls and 41 patients classified as group I or II, according to the Japanese classification. Genotyping was carried out by PCR, PCR-RFLP and pyrosequencing analysis. We did not find any association of the IL-1B-31, IL-1B-511 and IL-10 polymorphisms with the risk for developing gastric cancer in the studied population. Carriers of the IL-1B+3954T/— had an increased risk for developing gastric cancer (OR 3.7; 95%CI: 1.34-10.2). Also we found an increased risk for developing gastric cancer for allele 2 heterozygotes of the IL-IRN (OR 2.94; 95%CI: 1.09-7.93). This is the first time that IL-1B+3954 has been associated with gastric cancer. This is one of the first studies trying to describe the role played by IL-1B, IL-1RN and IL-10 genetic polymorphisms in gastric cancer in one of the highest risk American countries. Further investigation on American countries is needed.es_ES
dc.description.sponsorshipUniversidad de Costa Rica, Instituto de Investigaciones en Saludes_ES
dc.language.isoen_USes_ES
dc.publisherClinical and Experimental Medicine 5 p.169-176es_ES
dc.sourceClinical and Experimental Medicine 5(4): 169-176es_ES
dc.subjectInterleukin-1B polymorphismses_ES
dc.subjectInterleukin-10 polymorphismses_ES
dc.subjectHelicobacter pylories_ES
dc.subjectGastric canceres_ES
dc.subjectPro-inflammatory responsees_ES
dc.subjectInterleukin- IRN polymorphismses_ES
dc.titleAssociation of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Ricaes_ES
dc.typeartículo científico
dc.identifier.doi10.1007/s10238-005-0082-3
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES


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