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Mostrando ítems 171-180 de 195
Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: identification of key toxin targets for antivenom development.
(2015-04-24)
The venom proteome of the black mamba, Dendroaspis polylepis, from Eastern Africa, was, for the first time, characterized. Forty- different proteins and one nucleoside were identified or assigned to protein families. The ...
A novel pentameric phospholipase A2 myotoxin (PophPLA2) from the venom of the pit viper Porthidium ophryomegas
(2018-06-07)
The first toxin isolated from the venomous pit viper Porthidiumophryomegas is a basic pentameric phospholipase
A2 (PophPLA2). Elucidation of its amino acid sequence showed that it belongs to the group IIA of secreted ...
Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase
(2013-03-27)
Bothrops pirajai snake venom was analyzed by a proteomic strategy. Proteins were separated by RP-HPLC, followed by SDS-PAGE, in-gel tryptic digestion, identification by MALDI-TOF/TOF mass spectrometry, and assignment to ...
Varespladib (LY315920) and methyl Varespladib (LY333013) abrogate or delay lethality induced by presynaptically-acting neurotoxic snake venoms
(2020)
The phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA2 activity of a wide variety of snake venoms. In this study, the ability of these ...
Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose
(2010)
We report the proteomic characterization and biological activities of the venom of the black-speckled palm pitviper, Bothriechis nigroviridis, a neotropical arboreal pitviper from Costa Rica. In marked contrast to other ...
The recovery from the neuroparalysis caused by Micrurus nigrocinctus venom is accelerated by an agonist of the CXCR4 receptor
(2022)
Snake envenoming is a major but neglected human disease in tropical and subtropical regions. Among venomous snakes in the Americas, coral snakes of the genus Micrurus are particularly dangerous because they cause a peripheral ...
Phospholipases A2 From Viperidae Snake Venoms: How do They Induce Skeletal Muscle Damage?
(Acta Chim. Slov., 58, 647–659, 2011, 2011)
Phospholipases A2 (PLA2s) are abundant components in snake venoms, which play important toxic roles. This review
focuses on group II PLA2s endowed with myotoxic effects, present in Viperidae venoms. These PLA2s are ...
An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages
(2014)
Phospholipases A2 (PLA2) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression ...
Myotoxin-neutralizing peptides
PEPTIDES NEUTRALISANT LES MYOTOXINES
(2018-03-27)
The present invention relates to polypeptides having myotoxin-neutralizing properties and their use for treatment of envenomation. The present invention further relates to methods for neutralizing a venom using the polypeptide ...
Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom
(1992)
Two basic myotoxic phospholipases A2 were purified to homogeneity from the venom of Bothrops godmani from Costa Rica by ion-exchange chromatography on CM-Sephadex. They have molecular weights of 14,300 (myotoxin I) and ...