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An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica
(1988)
The ability of several batches of polyvalent antivenom to neutralize indirect hemolytic activity of Bothrops asper venom was studied using a sensitive plate test. All samples of antivenom tested effectively neutralized ...
Patogénesis y neutralización de los efectos locales inducidos por el veneno de la serpiente "terciopelo" (Bothrops asper).
(1982)
Se presenta la revisión de varias investigaciones sobre la patogénesis y neutralización de los efectos locales inducidos por el veneno de la serpiente terciopelo. El cuadro local está constituido por mionecrosis, hemorragia ...
Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae)
(2011-01-31)
The proteome of the venom of Micrurus nigrocinctus (Central American coral snake) was analyzed by a “venomics” approach. Nearly 50 venom peaks were resolved by RP-HPLC, revealing a complex protein composition. Comparative ...
Role of enzymatic activity inmuscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?
(Peer Journal 2:e569; DOI 10.7717/peerj.569, 2014-09-16)
Viperid venoms often contain mixtures of Asp49 and Lys49 PLA2 myotoxin isoforms,
relevant to development of myonecrosis. Given their difference in catalytic
activity, mechanistic studies on each type require highly ...
Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment
(2005-06)
Envenomations after bites inflicted by snakes of the genus Bothrops constitute a public health hazard in Perú, and the intravenous administration of equine-derived antivenoms represents the only scientifically validated ...
Modulation of the Susceptibility of Human Erythrocytes to Snake Venom Myotoxic Phospholipases A2: Role of Negatively Charged Phospholipids as Potential Membrane Binding Sites
(2001-07-01)
Cerrophidion (Bothrops) godmani myotoxins I (CGMT-I) and II (CGMT-II), Asp-49 and Lys-49 phospholipases A(2) (PLA2s), which drastically differ in enzymatic activity, were devoid of direct hemolytic effects on erythrocytes ...
Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism
(2009-11-02)
The venom proteomes of Bothrops atrox from Colombia, Brazil, Ecuador, and Perú were characterized using venomic and antivenomic strategies. Our results evidence the existence of two geographically differentiated venom ...
Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice
(1995-01)
The effect of several drugs on the edema-forming activity of Bothrops asper venom was studied plethysmographically using the mouse foot pad assay. Bothrops asper venom induced a dose-dependent edema which developed rapidly ...
Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro
(1994)
The effect of various crotalid and viperid venoms at 10, 50 and 100 μg/ml was examined on bovine and murine endothelial cells in vitro. The venoms caused the cells to lose their processes, leading to the appearance of ...
Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica
(1989)
The mode of action of a basic myotoxin isolated from Bothrops nummifer venom was studied. This myotoxin is a basic polypeptide of 13,000 mol.wt, with a high content of lysine and aspartate, as well as of hydrophobic amino ...