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Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA 

Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Franceschi, Aida; Chaves Mora, Fernando; León Montero, Guillermo; Cury, Yara; Ovadia, Michael; Gutiérrez, José María (2000-11)
The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice. Both ...
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Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves 

Hernández, Rosario; Cabalceta, Carmen; Saravia Otten, Patricia; Chaves, Alessandra; Gutiérrez, José María; Rucavado Romero, Alexandra (PLoS ONE 6(5): e19834, 2011-05-24)
Background: Viperid snakebite envenoming is characterized by prominent local tissue damage, including muscle necrosis. A frequent outcome of such local pathology is deficient skeletal muscle regeneration, which causes ...

Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms 

Gutiérrez, José María; Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Herrera Arias, Cristina; Fernández Ulate, Julián; Lomonte, Bruno; Fox, Jay W. (2018-06)
Snakebite envenoming by viperid species, and by some elapids, is characterized by a complex pattern of tissue damage at the anatomical site of venom injection. In severe cases, tissue destruction may be so extensive as ...

Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment 

Lomonte, Bruno; León Montero, Guillermo; Angulo Ugalde, Yamileth; Rucavado Romero, Alexandra; Núñez Rangel, Vitelbina (2009)
Interest in studies on the neutralization of snake venoms and toxins by diverse types of inhibitors is two-fold. From an applied perspective, results enclose the potential to be translated into useful therapeutic products ...

Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage 

Gutiérrez, José María; Rucavado Romero, Alexandra (2000-09-10)
The biochemical characteristics of hemorrhagic metalloproteinases isolated from snake venoms are reviewed, together with their role in the pathogenesis of the local tissue damage characteristic of crotaline and viperine ...
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Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom 

Rucavado Romero, Alexandra; Henríquez, Mónica; García, Jonielle; Gutiérrez, José María (2008-12-01)
Snake venom metalloproteinases (SVMPs) play a prominent role in the local and systemic manifestations of viperid snakebite envenomations. Thus, the possibility of using metalloproteinase inhibitors in the treatment of these ...
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Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper 

Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Teixeira, Catarina de Fátima; Fernandes, Cristina Maria; Díaz Oreiro, Cecilia; Gutiérrez, José María (2002)
Envenomations by the snake Bothrops asper are characterized by prominent local tissue damage (i.e. myonecrosis), blistering, hemorrhage and edema. Various phospholipases A2 and metalloproteinases that induce local pathological ...
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Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis 

Herrera Arias, Cristina; Macêdo, Jéssica Kele A.; Feoli Grant, Andrés; Escalante Muñoz, Teresa; Rucavado Romero, Alexandra; Gutiérrez, José María; Fox, Jay W. (2016-04-01)
The time-course of the pathological effects induced by the venom of the snake Bothrops asper in muscle tissue was investigated by a combination of histology, proteomic analysis of exudates collected in the vicinity of ...
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Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities 

Quesada Gómez, Carlos; López Ureña, Diana; Chumbler, Nicole; Kroh, Heather K.; Castro Peña, Carolina; Rodríguez Sánchez, César; Orozco Aguilar, Josué; González Camacho, Sara María; Rucavado Romero, Alexandra; Guzmán Verri, Caterina; Lawley, Trevor D.; Lacy, D. Borden; Chaves Olarte, Esteban (2016-03)
Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still ...

Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy 

Escalante Muñoz, Teresa; Rucavado Romero, Alexandra; Kamiguti, Aura S.; Theakston, R. David G.; Gutiérrez, José María (2004-02)
The ability of the P-I metalloproteinase BaP1, isolated from the venom of the snake Bothrops asper, to induce systemic bleeding, thrombocytopenia and defibrinogenation was assessed in an experimental mouse model. Intravenous ...
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Rucavado Romero, Alexandra (69)
Gutiérrez, José María (64)Escalante Muñoz, Teresa (29)Lomonte, Bruno (22)Fox, Jay W. (12)Angulo Ugalde, Yamileth (7)Calvete Chornet, Juan José (7)Díaz Oreiro, Cecilia (7)León Montero, Guillermo (6)Chaves Mora, Fernando (5)... View MoreTypeartículo científico (67)capítulo de libro (2)ProcedenceVicerrectoría de Investigación (69)Vicerrectoría de Docencia (7)... View MoreHas File(s)Yes (69)

  • Repositorios universitarios

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