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Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper
(2000-01)
A hemorrhagic metalloproteinase, named BaH4, was isolated from the venom of the snake Bothrops asper by a combination of ion-exchange chromatography on DEAE-Sepharose and gel filtration on Sephacryl S-200. BaH4 is a 69 kDa ...
The need for an integrated approach in confronting snakebite envenoming in Latin America: the relevance of endogenous scientific and technological research
Hacia un abordaje integral del envenenamiento ofídico en América Latina: la importancia de la generación de conocimiento científico-tecnológico endógeno
(2016)
Snakebite envenomings constitute a serious public health problem on a global level, especially in Africa,
Asia and Latin America. In our Latin American region, it is estimated that at least 70,000 snakebite
cases occur ...
Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom
(2009-12-01)
Moderate and severe envenomations by the snake Bothrops asper provoke systemic alterations, such as systemic bleeding, coagulopathy, hypovolemia, hemodynamic instability and shock, and acute renal failure. Systemic hemorrhage ...
Instituto Clodomiro Picado: Ciencia y Tecnología Endógenas en la Solución de un Problema de la Salud Pública en Centroamérica
(1999-05)
El accidente ofídico re-presenta un importante problema de salud pública en Centroamérica. En Costa Rica, por ejemplo, ocurren alrededor de 600 mordeduras por serpientes en humanos anualmente (Gutiérrez, 1995), en tanto ...
Envenamiento por mordedura de serpiente en Costa Rica en 1996: Epidemiología y consideraciones clínicas
(1999-12)
El presente trabajo se efectúa para tener una visión actualizada y completa de las principales características epidemiológicas del envenenamiento por mordedura de serpiente en Costa Rica. Asimismo, se incluyen algunas ...
Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action
(2008-06-20)
A large variety of snake toxins evolved from PLA2 digestive enzymes through a process of ‘accelerated evolution’. These toxins have different tissue targets, membrane receptors and mechanisms of alteration of the cell ...
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide
(2004-03)
Snakebites constitute a serious public health problem in Central and South America, where species of the lancehead pit vipers (genus Bothrops) cause the majority of accidents. Bothrops envenomations are very painful, and ...
Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia)
(1995-06)
This investigation compared the ability of six Latin American antivenoms (monovalent antibothropic INS, Santafé de Bogotá; polyvalent INS; polyvalent probiol, Santafé de Bogotá; antibothropic Instituto Butantan, IB, São ...
Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms
(2000-09)
Changes in serum levels of several cytokines and nitric oxide were studied in BALB/c mice injected intraperitoneally with one median lethal dose (LD(50)) of the venoms of Bothrops asper and Bothrops jararaca, two of the ...
The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper
(1990)
A myotoxic, basic phospholipase A2 (pI greater than 9.5) with anticoagulant activity has been purified from the venom of Bothrops asper, and its amino acid sequence determined by automated Edman degradation. It is distinct ...