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Mostrando ítems 11-20 de 36
The struggle of neglected scientific groups: ten years of NeTropica efforts to promote research in tropical diseases in Central America
(PLoS Neglected Tropical Diseases, 2011-07-26)
The general strategy used by high-income countries to address global health challenges in low- and middle-income countries (LMICs) relies heavily on short-term strategies designed to diminish the burden of diseases afflicting ...
Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect
(1994-08)
Bothrops asper myotoxin II was cleaved with cyanogen bromide to determine the role of NH2-terminal amino acid residues in its ability to destabilize negatively charged liposomes and to induce myonecrosis. After treatment, ...
Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu
(1991)
A myotoxic phospholipase A2, named bothropstoxin II (BthTX-II), was isolated from the venom of the South American snake Bothrops jararacussu and the pathogenesis of myonecrosis induced by this toxin was studied in mice. ...
Efectos locales en el envenenamiento ofídico en América Latina
(2003)
Los envenenamientos por mordedura de serpiente constituyen un importante problema de salud pública en América Latina. La gran mayoría de estos envenenamientos son causados por mordeduras de serpientes de la familia Viperidae, ...
Delayed oral LY333013 rescues mice from highly neurotoxic, lethal doses of Papuan Taipan (Oxyuranus scutellatus) venom
(2018)
There is an unmet need for economical snakebite therapies with long shelf lives
that are effective even with delays in treatment. The orally bioavailable, heat-stable, secretory
phospholipase A2 (sPLA2) inhibitor, LY333013, ...
Métodos de Investigación: destrezas básicas para el trabajo científico en las disciplinas biomédicas
(2020-10-01)
Esta obra didáctica nace con el objetivo de presentar a sus lectores una visión
introductoria sobre el fenómeno científico actual, sus orígenes, su contexto
costarricense, y posteriormente presentar las principales ...
Venenos de serpientes de la familia Viperidae en América: Bioquímica y fisiopatología.
(2011)
Se muestra una perspectiva general de las características bioquímicas de los principales tipos de toxinas
presentes en los venenos de vipéridos americanos y la fisiopatología de estos envenenamientos. En la preparación ...
Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom
(1992)
Two basic myotoxic phospholipases A2 were purified to homogeneity from the venom of Bothrops godmani from Costa Rica by ion-exchange chromatography on CM-Sephadex. They have molecular weights of 14,300 (myotoxin I) and ...
Innovative immunization strategies for antivenom development
(2018)
Snakes, scorpions, and spiders are venomous animals that pose a threat to human
health, and severe envenomings from the bites or stings of these animals must be treated with
antivenom. Current antivenoms are based on ...
Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom
(1995)
A basic myotoxic protein was purified from Bothrops asper venom. Like other basic Bothrops myotoxins, myotoxin IV induces acute muscle damage after intramuscular injection in mice and disrupts negatively charged liposomes ...