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Venom variation in Bothrops asper lineages from north-western South America. 

Mora Obando, Diana; Salazar Valenzuela, David; Pla Ferrer, Davinia; Lomonte, Bruno; Guerrero Vargas, Jimmy; Ayerbe, Santiago; Gibbs, H. Lisle; Calvete Chornet, Juan José (2020)
Bothrops asper is a venomous pitviper that is widely distributed and of clinical importance in Mesoamerica and northern South America, where it is responsible for 50–80% of all envenomations by Viperidae species. Previous ...
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Bases moleculares del reconocimiento de antígenos 

Lomonte, Bruno (1999)
Aunque todos los organismos pertenecientes al reino animal poseen una serie de mecanismos inmunitarios que persiguen mantener su integridad y rechazar la invasión de material foráneo, solo los vertebrados cuentan con un ...

Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation. 

Gutiérrez, José María; León Montero, Guillermo; Lomonte, Bruno (2003-07)
Parenteral administration of horse- and sheep-derived antivenoms constitutes the cornerstone in the therapy of envenomations induced by animal bites and stings. Depending on the type of neutralising molecule, antivenoms ...

A Lys49 phospholipase A2 homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line 

Mora Rodríguez, Rodrigo Antonio; Valverde Rojas, Berta E.; Díaz Oreiro, Cecilia; Lomonte, Bruno; Gutiérrez, José María (2005-04)
Lys49 phospholipase A2 homologues are abundant in viperid snake venoms. These proteins have substitutions at the calcium-binding loop and catalytic center which render them enzymatically inactive; however, they display a ...
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First insights into the venom composition of two Ecuadorian coral snakes 

Hernández Altamirano, Josselin A.; Salazar Valenzuela, David; Medina Villamizar, Evencio J.; Quirola, Diego R.; Patel, Ketan; Vaiyapuri, Sakthivel; Lomonte, Bruno; Almeida, José R. (2022)
Micrurus is a medically relevant genus of venomous snakes composed of 85 species. Bites caused by coral snakes are rare, but they are usually associated with very severe and life-threatening clinical manifestations. Ecuador ...
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A secreted phospholipase A2 induces formation of smooth muscle foam cells which trans-differentiate to macrophage-like state 

Giannotti, Karina Cristina; Weinert, Sönke; Viana, Mariana Nascimento; Leiguez, Elbio; Araujo, Thaís L. S.; Laurindo, Francisco R. M.; Lomonte, Bruno; Braun Dullaeus, Rüdiger; Teixeira, Catarina de Fátima (2019)
Vascular smooth muscle cells (VSMCs) loaded with lipid droplets (LDs) are markers of atherosclerosis. In this disease, inflammatory Group IIA-secreted phospholipase A2s (GIIA sPLA2s) are highly expressed in VSMCs, but ...

High-density peptide microarray exploration of the antibody response in a rabbit immunized with a neurotoxic venom fraction 

Engmark, Mikael Gerling; Jespersen, Martin Closter; Lomonte, Bruno; Lund, Ole; Laustsen, Andreas Hougaard (2017-11)
Polyvalent snakebite antivenoms derive their therapeutic success from the ability of their antibodies to neutralize venom toxins across multiple snake species. This ability results from a production process involving ...
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Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms 

Calvete Chornet, Juan José; Sanz, Libia; Pla Ferrer, Davinia; Lomonte, Bruno; Gutiérrez, José María (Toxins vol.6:3388-3405, 2014-12-15)
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact worldwide, mostly affecting poor people involved in agricultural activities in Africa, Asia, Latin America and Oceania. A ...

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties 

Lizano González, Sergio; Angulo Ugalde, Yamileth; Lomonte, Bruno; Fox, Jay W.; Lambeau, Gérard; Lazdunski, Michel; Gutiérrez, José María (2000-03-15)
Myotoxic phospholipases A2 (PLA2s; group II) account for most of the muscle-tissue damage that results from envenomation by viperid snakes. In the venom of the Godman's viper (Cerrophidion godmani, formerly Bothrops godmani), ...
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Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A2 and mediates its toxic activity 

Lina Massimino, Maria; Simonato, Morena; Spolaore, Barbara; Franchin, Cinzia; Arrigoni, Giorgio; Marin, Oriano; Monturiol Gross, Laura; Fernández Ulate, Julián; Lomonte, Bruno; Tonello, Fiorella (2018)
Phospholipases A2 are a major component of snake venoms. Some of them cause severe muscle necrosis through an unknown mechanism. Phospholipid hydrolysis is a possible explanation of their toxic action, but catalytic and ...
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  • Repositorios universitarios

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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.