Global genetic variation at nine short tandem repeat loci and implications on forensic genetics
artículo original
Fecha
2003-01Autor
Sun, Guangyun
McGarvey, Stephen T.
Bayoumi, Riad
Mulligan, Connie J.
Barrantes Mesén, Ramiro
Raskin, Salmo
Zhong, Yixi
Akey, Joshua
Chakraborty, Ranajit
Deka, Ranjan
Metadatos
Mostrar el registro completo del ítemResumen
We have studied genetic variation at nine autosomal short tandem repeat loci in 20 globally distributed
human populations defined by geographic and ethnic origins, viz., African, Caucasian, Asian, Native
American and Oceanic. The purpose of this study is to evaluate the utility and applicability of these nine
loci in forensic analysis in worldwide populations. The levels of genetic variation measured by number of
alleles, allele size variance and heterozygosity are high in all populations irrespective of their effective
sizes. Single- as well as multi-locus genotype frequencies are in conformity with the assumptions of
Hardy-Weinberg equilibrium. Further, alleles across the entire set of nine loci are mutually independent
in all populations. Gene diversity analysis shows that pooling of population data by major geographic
groupings does not introduce substructure effects beyond the levels recommended by the National
Research Council, validating the establishment of population databases based on major geographic and
ethnic groupings. A network tree based on genetic distances further supports this assertion, in which
populations of common ancestry cluster together. With respect to the power of discrimination and
exclusion probabilities, even the relatively reduced levels of genetic variation at these nine STR loci in
smaller and isolated populations provide an exclusionary power over 99%. However, in paternity testing
with unknown genotype of the mother, the power of exclusion could fall below 80% in some isolated
populations, and in such cases use of additional loci supplementing the battery of the nine loci is
recommended.
External link to the item
10.1038/sj.ejhg.5200902
Artículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2003
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Population structure and genetic connectivity 1 of the scalloped hammerhead shark (Sphyrna lewini) across nursery grounds from the Eastern Tropical Pacific: implications for management and conservation
Elizondo Sancho, Mariana; Rodríguez Arriatti, Yehudi Nafisa; Albertazzi Castro, Federico José; Bonilla Salazar, Adrián; Arauz Naranjo, Daniel; Arauz Vargas, Randall; Areano, Elisa; Ávalos Castillo, Cristopher; Brenes, Óscar; Chávez Calderón, Elpis Joan; Dominici Arosemena, Arturo; Espinoza Mendiola, Mario; Heidemeyer, Maike; Tavares, Rafael; Hernández, Sebastián (2022-09)Defining demographically independent units and understanding gene flow between them is essential for managing and conserving exploited populations. The scalloped hammerhead shark, Sphyrna lewini , is a coastal semi-oceanic ... -
Estudio intergeneracional de la mutación que causa la distrofia miotónica de tipo 1 en Costa Rica
Morales Montero, Fernando; Cuenca Berger, Patricia; Brian Gago, Roberto; Sittenfeld Appel, Mauricio; del Valle Carazo, Gerardo (Revista de Neurología 2003; 36: 20-25, 2003-01-01)Introduction. Myotonic dystrophy type 1 is a neuromuscular, degenerative and progressive disease, with an autosomal dominant pattern of inheritance, variable eTressivity and incomplete penetrance. The genetic defect is ... -
Genetic Diversification and Dispersal of Taro (Colocasia esculenta (L.) Schott)
Chaïr, Hana; Traore, R. E.; Duval, Marie-France; Rivallan, R.; Mukherjee, A.; Aboagye, L. M.; van Rensburg, Willem Sternberg Jansen; Andrianavalona, V.; Pinheiro de Carvalho, Miguel Angelo; Saborío Pozuelo, Francisco; Sri Prana, M.; Komolong, B.; Lawac, F.; Lebot, Vincent (2016-06-17)Taro (Colocasia esculenta (L.) Schott) is widely distributed in tropical and sub-tropical areas. However, its origin, diversification and dispersal remain unclear. While taro genetic diversity has been documented at the ...