dc.creator | Alpízar Alpízar, Warner | |
dc.creator | Schnack Nielsen, Boye | |
dc.creator | Sierra Ramos, Rafaela | |
dc.creator | Illemann, Martin | |
dc.creator | Ramírez, José A. | |
dc.creator | Arias, Adriana | |
dc.creator | Durán, Sundry | |
dc.creator | Skarstein, Arne | |
dc.creator | Ovrebo, Kjell | |
dc.creator | Lund, Leif R. | |
dc.creator | Laerum, Ole Didrik | |
dc.date.accessioned | 2015-04-13T22:47:03Z | |
dc.date.available | 2015-04-13T22:47:03Z | |
dc.date.issued | 2009-07-16 | |
dc.identifier.citation | http://onlinelibrary.wiley.com/doi/10.1002/ijc.24755/abstract | |
dc.identifier.uri | https://hdl.handle.net/10669/11381 | |
dc.description | artículo -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2009. | es_ES |
dc.description.abstract | Gastric cancer is the second cancer causing death worldwide. Both incidence and mortality rates vary according to
geographical regions. The receptor for urokinase plasminogen activator (uPAR) is involved in extracellular matrix degradation
by mediating cell surface associated plasminogen activation, and its presence on gastric cancer cells is linked to micrometastasis
and poor prognosis. Immunohistochemical analyses of a set of 44 gastric cancer lesions from Costa Rica showed
expression of uPAR in cancer cells in both intestinal subtype (14 of 27) and diffuse subtype (10 of 17). We compared the
expression pattern of uPAR in gastric cancers from a high-risk country (Costa Rica) with a low-risk country (Norway). We found
uPAR on gastric cancer cells in 24 of 44 cases (54%) from Costa Rica and in 13 of 23 cases (56%) from Norway. uPAR was
seen in macrophages and neutrophils in all cases. We also examined the nonneoplastic mucosa and found that uPAR was
more frequently seen in epithelial cells located at the luminal edge of the crypts in cases with Helicobacter pylori infection
than in similar epithelial cells in noninfected mucosa (p 5 0.033; v2 5 4.54). In conclusion, the expression of uPAR in cancer
cells in more than half of the gastric cancer cases suggests that their uPAR-positivity do not contribute to explain the
different mortality rates between the 2 countries, however, the actual prevalence of uPAR-positive cancer cells in the gastric
cancers may still provide prognostic information. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica
the Danish Cancer Society, the Lundbeck
Foundation, Haukeland University Hospital (Helse-Vest), | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/Universidad de Costa Rica///Costa Rica// | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/Danish Cancer Society///// | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/Lundbeck Foundation///// | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/Haukeland University Hospital (Helse-Vest)///// | es_ES |
dc.language.iso | en_US | es_ES |
dc.publisher | International Journal of Cancer 146 año 2009 p. 405–415 | es_ES |
dc.rights | Atribución-NoComercial 3.0 Costa Rica | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/cr/ | * |
dc.source | International Journal of Cancer 126: 405–415. 2010 | es_ES |
dc.subject | Cáncer | es_ES |
dc.subject | Helicobacter pylori | es_ES |
dc.subject | Immunohistochemistry | es_ES |
dc.subject | Gastric cancer | es_ES |
dc.subject | Gastritis | es_ES |
dc.subject | Salud pública | es_ES |
dc.title | Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high- and low-risk countries | es_ES |
dc.type | artículo científico | |
dc.identifier.doi | 10.1002/ijc.24755 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA) | es_ES |