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dc.creatorAlpízar Alpízar, Warner
dc.creatorSchnack Nielsen, Boye
dc.creatorSierra Ramos, Rafaela
dc.creatorIllemann, Martin
dc.creatorRamírez, José A.
dc.creatorArias, Adriana
dc.creatorDurán, Sundry
dc.creatorSkarstein, Arne
dc.creatorOvrebo, Kjell
dc.creatorLund, Leif R.
dc.creatorLaerum, Ole Didrik
dc.descriptionartículo -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2009.es_ES
dc.description.abstractGastric cancer is the second cancer causing death worldwide. Both incidence and mortality rates vary according to geographical regions. The receptor for urokinase plasminogen activator (uPAR) is involved in extracellular matrix degradation by mediating cell surface associated plasminogen activation, and its presence on gastric cancer cells is linked to micrometastasis and poor prognosis. Immunohistochemical analyses of a set of 44 gastric cancer lesions from Costa Rica showed expression of uPAR in cancer cells in both intestinal subtype (14 of 27) and diffuse subtype (10 of 17). We compared the expression pattern of uPAR in gastric cancers from a high-risk country (Costa Rica) with a low-risk country (Norway). We found uPAR on gastric cancer cells in 24 of 44 cases (54%) from Costa Rica and in 13 of 23 cases (56%) from Norway. uPAR was seen in macrophages and neutrophils in all cases. We also examined the nonneoplastic mucosa and found that uPAR was more frequently seen in epithelial cells located at the luminal edge of the crypts in cases with Helicobacter pylori infection than in similar epithelial cells in noninfected mucosa (p 5 0.033; v2 5 4.54). In conclusion, the expression of uPAR in cancer cells in more than half of the gastric cancer cases suggests that their uPAR-positivity do not contribute to explain the different mortality rates between the 2 countries, however, the actual prevalence of uPAR-positive cancer cells in the gastric cancers may still provide prognostic information.es_ES
dc.description.sponsorshipUniversidad de Costa Rica the Danish Cancer Society, the Lundbeck Foundation, Haukeland University Hospital (Helse-Vest),es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/Universidad de Costa Rica///Costa Rica//es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/Danish Cancer Society/////es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/Lundbeck Foundation/////es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/Haukeland University Hospital (Helse-Vest)/////es_ES
dc.publisherInternational Journal of Cancer 146 año 2009 p. 405–415es_ES
dc.rightsAtribución-NoComercial 3.0 Costa Rica*
dc.sourceInternational Journal of Cancer 126: 405–415. 2010es_ES
dc.subjectHelicobacter pylories_ES
dc.subjectGastric canceres_ES
dc.subjectSalud públicaes_ES
dc.titleUrokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high- and low-risk countrieses_ES
dc.typeartículo científico
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES

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