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The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders
dc.creator | Contreras Rojas, Javier | |
dc.creator | Camarena, Beatriz | |
dc.creator | Glahn, David C. | |
dc.creator | Dassori, Albana | |
dc.creator | Medina, Rolando | |
dc.creator | Contreras, Salvador | |
dc.creator | Ramírez, M. | |
dc.creator | Armas, Regina | |
dc.creator | Muñoz, Rodrigo | |
dc.creator | Mendoza Rodríguez, Ricardo | |
dc.creator | Raventós Vorst, Henriette | |
dc.creator | Ontiveros Sánchez de la Barquera, Jose Alfonso | |
dc.creator | Nicolini Sánchez, José Humberto | |
dc.creator | Palmer, R. | |
dc.creator | Escamilla, Michael | |
dc.creator | Hare, L. | |
dc.date.accessioned | 2014-05-15T22:14:55Z | |
dc.date.available | 2014-05-15T22:14:55Z | |
dc.date.issued | 2009-01-11 | |
dc.identifier.citation | http://www.ncbi.nlm.nih.gov/pubmed/19016667 | |
dc.identifier.uri | https://hdl.handle.net/10669/11058 | |
dc.description | artículo (arbitrado) -- Universidad de Costa Rica, Centro de Investigaciones en Biología Celular y Molecular. 2008 | es |
dc.description.abstract | Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families. Results: We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes (P < 0.02, odds ratio 2.18, 95% CI 1.10–4.20). Conclusion: The ss or sl genotype at the 5-HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness. | es |
dc.description.sponsorship | This work was supported by Grants #R01 MH60881 and R0160875 from the National Institute of Mental Health and the US ⁄CR Psychiatric Genetic Research Training Grant #D43TW006152-04 (PGID #115887) | es |
dc.language.iso | en_US | es |
dc.publisher | Acta Psychiatr Scand 2009: 119: 117–127 | es |
dc.subject | Salud mental | es |
dc.subject | Salud pública | es |
dc.subject | Psychosis | es |
dc.subject | Trastornos de la personalidad | es |
dc.title | The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders | es |
dc.type | artículo original | |
dc.identifier.doi | 10.1111/j.1600-0447.2008.01273.x | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM) | es |