Revista Médica de la UCR 6(2)

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RESEARCH IN COSTA RICA INVOLVING HUMAN BEINGS AND ITS IMPACT ON THE HEALTH OF COSTA RICANS
(2013-03-05 00:00:00) Granados Zúñiga, Jorge
We evaluate the benefits of clinical research carried out in Costa Rica from the published results and a sample of informed consent forms of approved protocols. We found 30 studies on 28 pharmaceuticals and 23 published scientific papers. Results: Of surveyed medical conditions, 19% are directly related to the main causes of mortality and morbidity in our country does not seem to have been necessary for drug registration. A placebo as control was ued in 27% of investigations; of all studies with results, 30% had not published results, 37% published positive results, 17% ambiguous or contradictory results and 13% ended prematurely. Out of the major authors responsible for the publications, 91% were affiliated with research centers abroad. Conclusions: We conclude that there is insufficient evidence to claim that analyzed clinical research has provided a significant benefit to the health of Costa Ricans, represents a significant therapeutic option, or has provided a significant contribution to scientific research in Costa Rica.