Venomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venoms
artículo original
Fecha
2016Autor
Sanz, Libia
Pla Ferrer, Davinia
Pérez, Alicia
Rodríguez, Yania
Zavaleta Martínez Vargas, Alfonso
Salas Arruz, María
Lomonte, Bruno
Calvete Chornet, Juan José
Metadatos
Mostrar el registro completo del ítemResumen
The venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii
was unveiled using a venomic approach, which identified ¥38 proteins belonging to only four snake
venom protein families. The three-finger toxins (3FTxs) constitute, both in number of isoforms
(~30) and total abundance (93.6% of the venom proteome), the major protein family of the desert
coral snake venom. Phospholipases A2 (PLA2s; seven isoforms, 4.1% of the venom proteome),
1–3 Kunitz-type proteins (1.6%), and 1–2 L-amino acid oxidases (LAO, 0.7%) complete the toxin
arsenal of M. t. tschudii. Our results add to the growing evidence that the occurrence of two divergent
venom phenotypes, i.e., 3FTx- and PLA2-predominant venom proteomes, may constitute a general
trend across the cladogenesis of Micrurus. The occurrence of a similar pattern of venom phenotypic
variability among true sea snake (Hydrophiinae) venoms suggests that the 3FTx/PLA2 dichotomy
may be widely distributed among Elapidae venoms.
External link to the item
10.3390/toxins8060178Colecciones
- Microbiología [1171]
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