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Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment
dc.creator | Lomonte, Bruno | |
dc.creator | León Montero, Guillermo | |
dc.creator | Angulo Ugalde, Yamileth | |
dc.creator | Rucavado Romero, Alexandra | |
dc.creator | Núñez Rangel, Vitelbina | |
dc.date.accessioned | 2018-03-13T16:46:07Z | |
dc.date.available | 2018-03-13T16:46:07Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | https://www.sciencedirect.com/science/article/pii/S0041010109001780 | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.uri | https://hdl.handle.net/10669/74299 | |
dc.description.abstract | Interest in studies on the neutralization of snake venoms and toxins by diverse types of inhibitors is two-fold. From an applied perspective, results enclose the potential to be translated into useful therapeutic products or procedures, to benefit patients suffering from envenomings. From a basic point of view, on the other hand, neutralizing agents may be used as powerful dissecting tools to determine the relative role of toxins within the context of the overall pathology induced by a venom, or to increase our understanding on the molecular mechanisms by which toxins exert their harmful actions upon particular targets. The venom of the snake Bothrops asper has been the subject of a number of experimental studies addressing its neutralization by antibodies, as well as by nonimmunologic inhibitors, including natural products derived from plants or animals, or synthetic drugs. As summarized in the present review, neutralization studies on this venom and some of its isolated toxins have contributed to a better understanding of envenomings by this species, and their treatment. In addition, such studies have provided valuable knowledge on the mechanisms of action and the relative functional importance of particular toxins of this venom, especially in the case of its myotoxic phospholipases A2 and hemorrhagic metalloproteinases. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica//UCR/Costa Rica | es_ES |
dc.description.sponsorship | Network for Research and Training in Tropical Diseases in Central America//NeTropica/ | es_ES |
dc.description.sponsorship | Universidad de Antioquia///Colombia | es_ES |
dc.description.sponsorship | Departamento Administrativo de Ciencia, Tecnología e Innovación//COLCIENCIAS/Colombia | es_ES |
dc.description.sponsorship | Wellcome Trust///Reino Unido | es_ES |
dc.description.sponsorship | International Foundation for Science//IFS/Suecia | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Toxicon, vol. 54(7), 1012-1028 | es_ES |
dc.subject | Antivenomics | es_ES |
dc.subject | Snake venom | es_ES |
dc.subject | Antibodies | es_ES |
dc.subject | Natural products | es_ES |
dc.title | Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1016/j.toxicon.2009.03.015 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicina | es_ES |
dc.identifier.pmid | 19324064 |
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