Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins
artículo original
Date
2013-02Author
Gutiérrez, José María
Lomonte, Bruno
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Show full item recordAbstract
Phospholipases A2 (PLA2s) are abundant components of snake venoms, where they play toxic and digestive roles. Despite having a similar three-dimensional structure, venom PLA2s exert an amazing variety of toxic and pharmacological effects, which include neurotoxic, myotoxic, hemolytic, edematogenic, hyperalgesic, pro-inflammatory, hypotensive, platelet-aggregation inhibitory, anticoagulant, cytotoxic, and bactericidal activities. Toxinologists have made significant contributions to deciphering the structure, molecular evolution, mechanisms of action, receptors, role of enzymatic activity for toxicity, structural determinants of toxicity and selectivity, and the impact of these enzymes in the overall pathophysiology of snakebite envenoming. The present work highlights some of the most relevant contributions in the study of venom PLA2s, including the personal accounts of the authors of these studies.
External link to the item
10.1016/j.toxicon.2012.09.006Collections
- Microbiología [1170]