Mostrar el registro sencillo del ítem
Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom
dc.creator | Gutiérrez, José María | |
dc.creator | Gené, José Antonio | |
dc.creator | Rojas Céspedes, Gustavo | |
dc.creator | Cerdas Fallas, Luis | |
dc.date.accessioned | 2016-11-03T20:51:39Z | |
dc.date.available | 2016-11-03T20:51:39Z | |
dc.date.issued | 1985 | |
dc.identifier.citation | http://www.sciencedirect.com/science/article/pii/0041010185903800 | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.uri | https://hdl.handle.net/10669/29142 | |
dc.description.abstract | The polyvalent antivenom produced at the Instituto Clodomiro Picado, Costa Rica, was tested for its capacity to neutralize proteolytic and hemorrhagic activities of ten Costa Rican crotaline venoms. In experiments with preincubation of venom and antivenom, the latter efficiently neutralized proteolytic activities of nine venoms, with ED50 ranging from 50 to 300 microliters antivenom/mg venom. The venom of Bothrops nummifer was neutralized less efficiently (ED50 = 760 microliters/mg.) Antivenom was also very effective in neutralizing hemorrhagic activity, having its lowest neutralizing ability against the venom of B. picadoi (ED = 430 microliters/mg) and its highest towards the venom of B. asper (Pacific region) (ED50 = 47 microliters/mg). There was a significant correlation between the ability of antivenom to neutralize proteolytic and hemorrhagic effects. In spite of the ability of antivenom to neutralize hemorrhage when incubated with venom prior to injection, hemorrhage was only partially neutralized when antivenom was administered i.v. at different time periods after envenomation. This suggests that the rapid development of local hemorrhage, instead of the absence of antivenom antibodies, is the explanation for the poor neutralization observed in these types of experiments. | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Toxicon Volumen 23, Número 6, 1985 | es_ES |
dc.subject | Animals | es_ES |
dc.subject | Pharmacology | es_ES |
dc.subject | Crotalid Venoms | es_ES |
dc.subject | Hemorrhage | es_ES |
dc.subject | Chemically Induced | es_ES |
dc.title | Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1016/0041-0101(85)90380-0 | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Biología [1644]