Meta-analysis of 32 genome-wide linkage studies of schizophrenia
artículo preliminar
Date
2008-12-30Author
Ng, Mandy Y. M.
Levinson, Doug
Faraone, Stephen V.
Suárez, Brian K.
DeLisi, Lynn E.
Arinami, Tadao
Riley, Brien
Paunio, Tiina
Pulver, Ann E.
Irmansyah, Irman
Holmans, Peter A.
Escamilla, Michael
Wildenauer, Dieter B.
Williams, Nigel M.
Laurent, Claudine
Mowry, Bryan J.
Brzustowicz, Linda M.
Maziade, Michel
Sklar, Pamela
Garver, David L.
Abecasis, Gonçalo R.
Lerer, Benjamin
Fallin, Margaret D.
Gurling, Hugh M. D.
Gejman, Pablo V.
Lindholm, Eva
Moises, Hans W.
Byerley, William
Wijsman, Ellen M.
Forabosco, Paola
Tsuang, Ming T.
Hwu, Hai-Gwo
Okazaki, Yuji
Kendler, Kenneth S.
Wormley, Brandon
Fanous, Ayman
Walsh, Dermot
O'Neill, Francis A.
Peltonen, Leena
Nestadt, Gerald
Lasseter, Virginia K.
Liang, Kung-Yee
Papadimitriou, G. M.
Dikeos, D. G.
Schwab, Sybille G.
Owen, Michael J.
O'Donovan, Michael C.
Norton, Nancy
Hare, Elizabeth
Raventós Vorst, Henriette
Nicolini Sánchez, José Humberto
Albus, Margot
Maier, Wolfgang
Nimgaonkar, Vishwajit L.
Terenius, Lars
Mallet, Jacques
Jay, M.
Godard Bauché, Stéphanie
Nertney, Deborah A.
Alexander, M.
Crowe, R. R.
Silverman, Jeremy M.
Bassett, Anne
Roy, M-A.
Mérette, Chantal
Pato, C. N.
Pato, Michele T.
Roos, J. Louw
Kohn, Y.
Amann Zalcenstein, Daniela
Kalsi, G.
McQuillin, Andrew
Curtis, David F.
Brynjolfson, J.
Sigmundsson, T.
Petursson, H.
Sanders, A. R.
Duan, Jubao
Jazin, E.
Myles Worsley, M.
Karayiorgou, Maria
Lewis, Cathryn M.
Metadata
Show full item recordAbstract
A genome scan meta analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for each bin across studies and determined the empirical probability of a given summed rank (PSR) by simulation. Suggestive evidence for linkage was observed in two single bins, on chromosomes 5q (142–168 Mb) and 2q (103–134 Mb). Genome-wide evidence for linkage was detected on chromosome 2q (119– 152 Mb) when bin boundaries were shifted to the middle of the previous bins. The primary analysis met empirical criteria for ‘aggregate’ genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q. In a secondary analysis of 22 studies of European-ancestry samples, suggestive evidence for linkage was observed on chromosome 8p (16–33 Mb). Although the newer genome-wide association methodology has greater power to detect weak associations to single common DNA sequence variants, linkage analysis can detect diverse genetic effects that segregate in families, including multiple rare variants within one locus or several weakly associated loci in the same region. Therefore, the regions supported by this meta-analysis deserve close attention in future studies.
External link to the item
10.1038/mp.2008.135
artículo (arbitrado) -- Universidad de Costa Rica. Centro de Investigación en Biología Celular y Molecular, 2008.