dc.creator | Escamilla, Michael | |
dc.creator | Dae Lee, Byung | |
dc.creator | Ontiveros Sánchez de la Barquera, Jose Alfonso | |
dc.creator | Nicolini Sánchez, José Humberto | |
dc.creator | Mendoza Rodríguez, Ricardo | |
dc.creator | Muñoz, Rodrigo | |
dc.creator | Medina, Rolando | |
dc.creator | Walss Bass, Consuelo | |
dc.creator | Armas, Regina | |
dc.creator | Contreras, Salvador | |
dc.creator | Dassori, Albana | |
dc.creator | Raventós Vorst, Henriette | |
dc.creator | Jerez, Álvaro | |
dc.creator | Figueroa, Andrés | |
dc.creator | Ramírez, Mercedes | |
dc.date.accessioned | 2014-03-07T20:07:48Z | |
dc.date.available | 2014-03-07T20:07:48Z | |
dc.date.issued | 2008-10-20 | |
dc.identifier.citation | http://www.schres-journal.com/article/S0920-9964(08)00412-X/abstract | |
dc.identifier.issn | 0920-9964 | |
dc.identifier.other | essn: 1573-2509 | |
dc.identifier.uri | https://hdl.handle.net/10669/9242 | |
dc.description | artículo (arbitrado). Universidad de Costa Rica, Centro de Investigación en Biología Celular y Molecular, 2008. Este artículo es privado debido a limitaciones de derechos de autor. | es |
dc.description.abstract | This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes
enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of
families segregating schizophrenia drawn from the Latin American population. 1423 subjects
(767 with a history of psychosis) from 337 Latino families were genotyped using three single
nucleotide polymorphisms (SNPs) spanning the Epsin 4 gene. A family based association test
was utilized to test for association of these SNPs to the phenotypes of psychosis and
schizophrenia. Haplotypes defined by these three SNPs showed significant association to the
phenotype of psychosis in this sample (global p value=0.014, bi-allelic p value=0.047).
Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino
population. This provides additional support for the involvement of enthoprotin in the
pathogenesis of schizophrenia and other psychotic disorders. | es |
dc.description.sponsorship | Universidad de Costa Rica | es |
dc.language.iso | en_US | es |
dc.publisher | Schizophrenia Research vol. 106, num 2 (2008) 253–257 | es |
dc.subject | Gen Epsin 4 | es |
dc.subject | Esquizofrenia | es |
dc.subject | Fenotipo | es |
dc.subject | América Latina | es |
dc.subject | Nucléotido | es |
dc.title | The epsin 4 gene is associated with psychotic disorders in families of Latin American origin | es |
dc.type | artículo original | |
dc.identifier.doi | http://dx.doi.org/10.1016/j.schres.2008.09.005 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM) | es |