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dc.creatorEscamilla, Michael
dc.creatorDae Lee, Byung
dc.creatorOntiveros Sánchez de la Barquera, Jose Alfonso
dc.creatorNicolini Sánchez, José Humberto
dc.creatorMendoza Rodríguez, Ricardo
dc.creatorMuñoz, Rodrigo
dc.creatorMedina, Rolando
dc.creatorWalss Bass, Consuelo
dc.creatorArmas, Regina
dc.creatorContreras, Salvador
dc.creatorDassori, Albana
dc.creatorRaventós Vorst, Henriette
dc.creatorJerez, Álvaro
dc.creatorFigueroa, Andrés
dc.creatorRamírez, Mercedes
dc.date.accessioned2014-03-07T20:07:48Z
dc.date.available2014-03-07T20:07:48Z
dc.date.issued2008-10-20
dc.identifier.citationhttp://www.schres-journal.com/article/S0920-9964(08)00412-X/abstractes
dc.identifier.issn0920-9964
dc.identifier.otheressn: 1573-2509
dc.identifier.urihttp://hdl.handle.net/10669/9242
dc.descriptionartículo (arbitrado). Universidad de Costa Rica, Centro de Investigación en Biología Celular y Molecular, 2008. Este artículo es privado debido a limitaciones de derechos de autor.es
dc.description.abstractThis study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia drawn from the Latin American population. 1423 subjects (767 with a history of psychosis) from 337 Latino families were genotyped using three single nucleotide polymorphisms (SNPs) spanning the Epsin 4 gene. A family based association test was utilized to test for association of these SNPs to the phenotypes of psychosis and schizophrenia. Haplotypes defined by these three SNPs showed significant association to the phenotype of psychosis in this sample (global p value=0.014, bi-allelic p value=0.047). Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population. This provides additional support for the involvement of enthoprotin in the pathogenesis of schizophrenia and other psychotic disorders.es
dc.description.sponsorshipUniversidad de Costa Ricaes
dc.language.isoen_USes
dc.publisherSchizophrenia Research vol. 106, num 2 (2008) 253–257es
dc.subjectGen Epsin 4es
dc.subjectEsquizofreniaes
dc.subjectFenotipoes
dc.subjectAmérica Latinaes
dc.subjectNucléotidoes
dc.titleThe epsin 4 gene is associated with psychotic disorders in families of Latin American origines
dc.typeArtículo científicoes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttp://dx.doi.org/10.1016/j.schres.2008.09.005
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es


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