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Effect of Apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica
dc.creator | Yang, Yadong | |
dc.creator | Ruiz Narváez, Edward A. | |
dc.creator | Kraft, Peter | |
dc.creator | Campos Núñez, Hannia | |
dc.date.accessioned | 2020-05-22T15:48:15Z | |
dc.date.available | 2020-05-22T15:48:15Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | https://digitalcommons.wayne.edu/humbiol/vol79/iss6/4/ | |
dc.identifier.issn | 0018-7143 | |
dc.identifier.uri | https://hdl.handle.net/10669/81086 | |
dc.description.abstract | We assessed the effect of APOE polymorphisms−491 A/T, C112R (APOE*4), and R158C (APOE*2) and saturated fat intake on plasma lipid levels and risk of myocardial infarction (MI) in 1,927 case subjects and 1,927 population-based control subjects matched for age, sex, and residence, all living in the Central Valley of Costa Rica. A significant gene-diet interaction ( p = 0.0157) was observed. High saturated fat intake was associated with a 49% increased risk of MI (OR = 1.49; 95% CI, 1.16–1.92) among wildtype subjects. In contrast, high saturated fat intake was associated with a 2.2- fold increased risk of MI among carriers of APOE*2 (OR = 3.17; 95% CI, 1.58–6.36) and with a 1.6-fold increase among carriers of the −491T and APOE*4 variants together (OR = 2.59; 95% CI, 1.38–4.87). Consistently, a high fat diet elicited a greater response in LDL cholesterol among carriers of APOE*2 (+17%) and APOE*4 (+14%) compared to noncarriers (+6%). The frequency of APOE variants was similar in case and control subjects, although APOE*4 homozygotes were at increased risk of MI compared to noncarriers (OR = 2.26; 95% CI, 1.03–4.98). This study supports the hypothesis that the APOE*2 and APOE*4 variants increase susceptibility to MI in the presence of high saturated fat and could explain inconsistent findings on the effects of these variants on MI in various populations. | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Human Biology, vol.79(6), pp.637-647 | es_ES |
dc.subject | Costa Rica | es_ES |
dc.subject | Myocardial Infarction | es_ES |
dc.subject | Saturated fats | es_ES |
dc.subject | Diet | es_ES |
dc.subject | Apolipoprotein E Genotype | es_ES |
dc.title | Effect of Apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica | es_ES |
dc.type | artículo original | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP) | es_ES |
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