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dc.creatorMadrigal Redondo, German
dc.creatorVargas Zúñiga, Rolando
dc.creatorCarazo Berrocal, Gustavo
dc.creatorRamírez Arguedas, Nils Antonio
dc.creatorFonseca González, Lidiette
dc.creatorCampos Fernández, Jorge Alberto
dc.date.accessioned2020-04-29T13:54:13Z
dc.date.available2020-04-29T13:54:13Z
dc.date.issued2017
dc.identifier.citationhttps://ijpni.org/Abstract/IJPNI_176_20170220063207es_ES
dc.identifier.issn2374-0639
dc.identifier.urihttp://hdl.handle.net/10669/80942
dc.description.abstractThere are more than 700 species of the genus Rubus, popularly known as Mora (tropical highland blackberry). In Costa Rica, the species Rubus adenotrichus has been characterized by its high content of antioxidant substances, becoming one of the most cultivated species and that may have characteristics to be used in cosmetics or medicine. The objective of the present study is to identify the main phytochemical groups and to quantify the main markers in order to associate them with cosmetic or medicinal functions in pharmaceutical products. Ripe fruits of Rubus adenotrichius were fractionated with solvents of low, medium and high polarity, followed by a phytochemical screening according to the World Health Organization Guidelines for the Control of Quality of Products of Natural Origin. The antioxidant properties were evaluated by means of the H-ORAC and DPPH test; the concentration of total phenols by Folin-Ciocalteau and antocinanins by differential pH was determined. Finally, the physicochemical properties of the aqueous extract, such as pH, specific gravity, Brix grades, conductivity, and osmolarity was determined and an absorption spectrum from 260 to 700 nm was obtained. Phenolic compounds were found as condensed and non-condensed tannins, anthocyanins, flavonoids, terpenes, and alkaloids as major phytochemical groups, a high antioxidant power measured in H-ORAC 311 ± 7.63 μg/mol Trolox Equivalent/g of dry fruit, and EC 50 118.46 mg/L for the aqueous extract. The total phenols found was 20.85 ± 0.27 mg/g of dry sample of gallic acid equivalents which makes the Rubus adenotrichus fruit an excellent component for bacteriostatic, anti-aging, anti-wrinkle, nourishing and moisturizing formulations, and the astringent effect also allows its application to small superficial wounds on the skin. Likewise, the acidic pH of 3.55 ± 0.1 is beneficial for maintaining the cutaneous acid mantle thereby favoring the normal flora of the skin, but may be a problem for the formulation of carbomer-based gels or the incorporation of preservatives. The aqueous extract is hyperosmotic (559.66 ± 3.21 mOs/kg) and has a high electrical conductivity (285 ± 2 μS/cm) due to the presence of electrolytes and a considerable amount of sugars, according to Brix degrees (7.543° ± 0.005°). Finally, the 4% w/w aqueous extract shows an absorption of ultraviolet radiation of 25% in the wavelengths from 260 to 400nm, by which it also could be useful for formulating compositions for sun protection.es_ES
dc.language.isoen_USes_ES
dc.sourceInternational Journal of Phytocosmetics and Natural Ingredients, vol.4(1), pp. 1-10es_ES
dc.subjectRubus adenotrichuses_ES
dc.subjectBlackberryes_ES
dc.subjectAntioxidantes_ES
dc.subjectPhytochemical screeninges_ES
dc.subjectCosmetices_ES
dc.titleRubus adenotrichus fruit extracts phytochemical characterization and antioxidant power evaluation for dermocosmetic formulationses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.15171/ijpni.2017.05
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES


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