The antimicrobial potential of Streptomyces from insect microbiomes
artículo original
Fecha
2019Autor
Chevrette, Marc G.
Carlson, Caitlin M.
Ortega Dominguez, Humberto Enrique
Thomas, Christopher S.
Ananiev, Gene E.
Barns, Kenneth J.
Book, Adam J.
Cagnazzo, Julian
Carlos Shanley, Camila
Flanigan, Will
Grubbs, Kirk J.
Horn, Heidi A.
Hoffmann, F. Michael
Klassen, Jonathan L.
Knack, Jennifer J.
Lewin, Gina R.
McDonald, Bradon R.
Muller, Laura K.
Melo, Weilan Gomes da Paixão
Pinto Tomás, Adrián A.
Schmitz, Amber Marie
Wendt-Pienkowski, Evelyn
Wildman, Scott
Zhao, Miao
Zhang, Fan
Bugni, Tim S.
Andes, David R.
Pupo, Monica Tallarico
Currie, Cameron Robert
Metadatos
Mostrar el registro completo del ítemResumen
Antimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known compounds. Investigation of understudied and symbiotic sources has seen some success, yet no studies have systematically explored microbiomes for antimicrobials. Here we assess the distinct evolutionary lineages of Streptomyces from insect microbiomes as a source of new antimicrobials through large-scale isolations, bioactivity assays, genomics, metabolomics, and in vivo infection models. Insect-associated Streptomyces inhibit antimicrobial-resistant pathogens more than soil Streptomyces. Genomics and metabolomics reveal their diverse biosynthetic capabilities. Further, we describe cyphomycin, a new molecule active against multidrug resistant fungal pathogens. The evolutionary trajectories of Streptomyces from the insect microbiome influence their biosynthetic potential and ability to inhibit resistant pathogens, supporting the promise of this source in augmenting future antimicrobial discovery.
External link to the item
10.1038/s41467-019-08438-0Colecciones
- Microbiología [1170]