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dc.creatorContreras Rojas, Javier
dc.creatorHare, Elizabeth
dc.creatorChavarría Soley, Gabriela
dc.creatorRaventós Vorst, Henriette
dc.date.accessioned2019-09-11T15:09:57Z
dc.date.available2019-09-11T15:09:57Z
dc.date.issued2017
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0165032717320074?via%3Dihubes_ES
dc.identifier.issn0165-0327
dc.identifier.urihttp://hdl.handle.net/10669/79110
dc.description.abstractBackground Genetic studies have been consistent that bipolar disorder type I (BPI) runs in families and that this familial aggregation is strongly influenced by genes. In a preliminary study, we proved that anxiety trait meets endophenotype criteria for BPI. Methods We assessed 619 individuals from the Central Valley of Costa Rica (CVCR) who have received evaluation for anxiety following the same methodological procedure used for the initial pilot study. Our goal was to conduct a multipoint quantitative trait linkage analysis to identify quantitative trait loci (QTLs) related to anxiety trait in subjects with BPI. We conducted the statistical analyses using Quantitative Trait Loci method (Variance-components models), implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR), using 5606 single nucleotide polymorphism (SNPs). Results We identified a suggestive linkage signal with a LOD score of 2.01 at chromosome 2 (2q13-q14). Limitations Since confounding factors such as substance abuse, medical illness and medication history were not assessed in our study, these conclusions should be taken as preliminary. Conclusions We conclude that region 2q13-q14 may harbor a candidate gene(s) with an important role in the pathophysiology of BPI and anxiety.es_ES
dc.description.sponsorshipNational Institute of Mental Health/[1R01TW008290-01A1]/NIMH/Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceJournal of Affective Disorders, vol 234, pp. 105-108es_ES
dc.subjectAnxietyes_ES
dc.subjectBipolar disorderes_ES
dc.subjectGenetic studieses_ES
dc.subjectQuantitative trait linkage analysises_ES
dc.subjectEndophenotypees_ES
dc.titleGenome-wide QTL analysis for anxiety trait in bipolar disorder type Ies_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/j.jad.2017.12.019
dc.description.procedenceUCR::Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologíaes_ES
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es_ES


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