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Streptococcus pneumoniae Upper Respiratory Carriage in Costa Rican Children with Otitis Media before the Introduction of the Heptavalent Conjugated Vaccine in the National Immunization Program
dc.creator | Ulloa, Catalina | |
dc.creator | Pereira Céspedes, Alfonso | |
dc.creator | Soley Gutiérrez, Carolina | |
dc.creator | Porat, Nurith | |
dc.creator | Abdelnour Vásquez, Arturo | |
dc.creator | Dagan, Ron | |
dc.creator | Arguedas Mohs, Adriano | |
dc.date.accessioned | 2019-06-24T14:59:09Z | |
dc.date.available | 2019-06-24T14:59:09Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | https://www.scirp.org/journal/PaperInformation.aspx?PaperID=31502 | |
dc.identifier.issn | 2160-5823 | |
dc.identifier.uri | https://hdl.handle.net/10669/77453 | |
dc.description.abstract | Objective: The aim of this study was to analyze the NP/OP S. pneumoniae serotype distribution and potential vaccine coverage in Costa Rican children with Otitis Media (OM) before the introduction of PCV-7 in the National Immunization Program (NIP). Methods: Between 2002 and 2006, NP and OP samples were obtained from 641 children from 6 to 79 months of age, at the time of OM diagnosis. S. pneumoniae serotyping and antimicrobial susceptibility were performed. Results: 386 S. pneumoniae isolates were recovered. The most common S. pneumoniae serotypes (ST) were: ST 6B, ST 14, ST 19F. Penicillin non-susceptibility was observed among 57% of the isolates obtained from children < 24 months of age. 15% strains were multidrug resistant. Potential vaccine coverage was: PCV-7: 60%; PCV-10: 62%; and PCV-13: 76% and against penicillin non-susceptible and multidrug resistant isolates was: PCV-7; 59% and 83%, respectively; PCV-10: 60% and 85%, respectively and PCV-13: 74% and 96%, respectively. Conclusions: S. pneumoniae was isolated from the NP and/or OP in the majority (59%) of studied children with OM. At a statistical significant level, only serotype 3 was more frequently isolated among children >24 months of age. Antibiotic non-susceptibility and MDR were significantly higher in children <24 months of age. This study demonstrates that PCV-13 offers the highest potential vaccine coverage and serves to assess the impact of introduction of one of the conjugated vaccines in the NIP in Costa Rica. | es_ES |
dc.language.iso | en_US | es_ES |
dc.rights | CC0 1.0 Universal | * |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.source | World Journal of Vaccines; vol.3(2), pp. 39-45 | es_ES |
dc.subject | Streptococcus pneumoniae | es_ES |
dc.subject | Serotypes | es_ES |
dc.subject | Nasopharynx | es_ES |
dc.subject | Oropharynx | es_ES |
dc.subject | Pneumococcal Conjugated Vaccine | es_ES |
dc.subject | 616. 208 372 86 Enfermedades del sistema respiratorio | es_ES |
dc.title | Streptococcus pneumoniae Upper Respiratory Carriage in Costa Rican Children with Otitis Media before the Introduction of the Heptavalent Conjugated Vaccine in the National Immunization Program | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.4236/wjv.2013.32007 | |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Salud::Facultad de Farmacia | es_ES |
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