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dc.creatorBrenes Sáenz, Juan Carlos
dc.creatorLackinger, Martin
dc.creatorHöglinger, Günter U.
dc.creatorSchratt, Gerhard
dc.creatorSchwarting, Rainer K. W.
dc.creatorWöhr, Markus
dc.date.accessioned2019-05-30T21:51:25Z
dc.date.available2019-05-30T21:51:25Z
dc.date.issued2015-07-01
dc.identifier.citationhttps://onlinelibrary.wiley.com/doi/full/10.1002/cne.23842
dc.identifier.issn1096-9861
dc.identifier.urihttps://hdl.handle.net/10669/77374
dc.description.abstractEnvironmental enrichment (EE) exerts beneficial effects on brain plasticity, cognition, and anxiety/depression, leading to a brain that can counteract deficits underlying various brain disorders. Because the complexity of the EE commonly used makes it difficult to identify causal aspects, we examined possible factors using a 2 X 2 design with social EE (two vs. six rats) and physical EE (physically enriched vs. nonenriched). For the first time, we demonstrate that social and physical EE have differential effects on brain plasticity, cognition,and ultrasonic communication. Expectedly, physical EE promoted neurogenesis in the dentate gyrus of the hippocampal formation, but not in the subventricular zone, and, as a novel finding, affected microRNA expression levels, with the activity-dependent miR-124 and miR-132 being upregulated. Concomitant improvements in cognition were observed, yet social deficits were seen in the emission of prosocial 50-kHz ultrasonic vocalizations (USV) paralleled by a lack of social approach in response to them, consistent with the intense world syndrome/theory of autism. In contrast, social EE had only minor effects on brain plasticity and cognition, but led to increased prosocial 50-kHz USV emission rates and enhanced social approach behavior. Importantly, social deficits following physical EE were prevented by additional social EE. The finding that social EE has positive whereas physical EE has negative effects on social behavior indicates that preclinical studies focusing on EE as a potential treatment in models for neuropsychiatric isorders haracterized by social deficits, such as autism, should include social EE in ddition to hysical EE, because its lack might worsen social deficits.J. Comp. Neurol. 524:1586–1607, 2016.es_ES
dc.description.sponsorshipThe Deutsche Forschungsgemeinschaft/[HO2402/6‐1]/DFG/Germanyes_ES
dc.description.sponsorshipThe Deutsche Forschungsgemeinschaft/[SCHR1136/3‐1]/DFG/Germanyes_ES
dc.description.sponsorshipThe Deutsche Forschungsgemeinschaft/[SCHW559/10‐1]/DFG/Germanyes_ES
dc.description.sponsorshipThe Deutsche Forschungsgemeinschaft/[WO1732/4‐1]/DFG/Germanyes_ES
dc.language.isoen_USes_ES
dc.sourceThe Journal of Comparative Neurology, vol.524, pp. 1586-1607es_ES
dc.subjectEnriched environmentes_ES
dc.subjectNeurogenesises_ES
dc.subjectMicroRNAes_ES
dc.subjectLearning and memoryes_ES
dc.subjectUltrasonic vocalizationes_ES
dc.subjectSocial behaviores_ES
dc.subjectAutismes_ES
dc.subjectRRID: AB_10013660es_ES
dc.subjectRRID: AB_2160651es_ES
dc.subjectRRID: nif-0000-3092es_ES
dc.subjectRRID: nif-0000-30176es_ES
dc.subjectRRID: nlx_152478; nlx_144442es_ES
dc.subject618.93 Roedores y conejoses_ES
dc.titleDifferential effects of social and physical environmental enrichment on brain plasticity, cognition, and ultrasonic communication in ratses_ES
dc.typeartículo original
dc.identifier.doi10.1002/cne.23842
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)


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