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dc.creatorFlores Díaz, Marietta
dc.creatorMonturiol Gross, Laura
dc.creatorNaylor, Claire E.
dc.creatorAlape Girón, Alberto
dc.creatorFlieger, Antje
dc.date.accessioned2019-04-05T21:09:18Z
dc.date.available2019-04-05T21:09:18Z
dc.date.issued2016-06-15
dc.identifier.citationhttps://mmbr.asm.org/content/80/3/597es_ES
dc.identifier.issn1098-5557
dc.identifier.urihttp://hdl.handle.net/10669/76867
dc.description.abstractBacterial sphingomyelinases and phospholipases are a heterogeneous group of esterases which are usually surface associated or secreted by a wide variety of Gram-positive and Gram-negative bacteria. These enzymes hydrolyze sphingomyelin and glycerophospholipids, respectively, generating products identical to the ones produced by eukaryotic enzymes which play crucial roles in distinct physiological processes, including membrane dynamics, cellular signaling, migration, growth, and death. Several bacterial sphingomyelinases and phospholipases are essential for virulence of extracellular, facultative, or obligate intracellular pathogens, as these enzymes contribute to phagosomal escape or phagosomal maturation avoidance, favoring tissue colonization, infection establishment and progression, or immune response evasion. This work presents a classification proposal for bacterial sphingomyelinases and phospholipases that considers not only their enzymatic activities but also their structural aspects. An overview of the main physiopathological activities is provided for each enzyme type, as are examples in which inactivation of a sphingomyelinaseor a phospholipase-encoding gene impairs the virulence of a pathogen. The identification of sphingomyelinases and phospholipases important for bacterial pathogenesis and the development of inhibitors for these enzymes could generate candidate vaccines and therapeutic agents, which will diminish the impacts of the associated human and animal diseases.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B1-601]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B1-603]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A9-503]/UCR/Costa Ricaes_ES
dc.description.sponsorshipConsejo Nacional de Rectores/[FR 6441]/CONARE/Costa Ricaes_ES
dc.description.sponsorshipMinisterio de Ciencia, Tecnología y Telecomunicaciones/[FR 1471]MICITT/Costa Ricaes_ES
dc.description.sponsorshipFundación Alemana de Investigación Científica/[DFG FL359/4-3]/DFG/Alemaniaes_ES
dc.description.sponsorshipFundación Alemana de Investigación Científica/[DFG FL359/6-1]/DFG/Alemaniaes_ES
dc.description.sponsorshipFundación Alemana de Investigación Científica/[DFG FL359/6-2]/DFG/Alemaniaes_ES
dc.description.sponsorshipFundación Alemana de Investigación Científica/[DFG FL359/7.1]/DFG/Alemaniaes_ES
dc.language.isoen_USes_ES
dc.sourceMicrobiology and Molecular Biology Reviews, vol. 80(3) pp. 597-628es_ES
dc.subjectBacteriases_ES
dc.subjectFactores de virulenciaes_ES
dc.subject579.3 Procariotas (Bacterias)es_ES
dc.titleBacterial Sphingomyelinases and Phospholipases as Virulence Factorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1128/MMBR.00082-15
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiologíaes_ES
dc.identifier.codproyecto741-B1-601
dc.identifier.codproyecto741-B1-603
dc.identifier.codproyecto741-A9-503


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