Logo Kérwá
 

Pros and cons of different therapeutic antibody formats for recombinant antivenom development

Loading...
Thumbnail Image

Authors

Laustsen, Andreas Hougaard
Gutiérrez, José María
Knudsen, Cecilie
Johansen, Kristoffer H.
Bermúdez Méndez, Erick
Cerni, Felipe A.
Jürgensen, Jonas A.
Ledsgaard, Line
Martos Esteban, Andrea
Øhlenschlæger, Mia

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being investigated for the ability to neutralize animal toxins. These different molecular formats each have their own therapeutic characteristics. In this review, we provide an overview of the advances made in the development of toxin-targeting antibodies, and discuss the benefits and drawbacks of different antibody formats in relation to their ability to neutralize toxins, pharmacokinetic features, propensity to cause adverse reactions, formulation, and expression for research and development (R&D) purposes and large-scale manufacturing. A research trend seems to be emerging towards the use of human antibody formats as well as camelid heavy-domain antibody fragments due to their compatibility with the human immune system, beneficial therapeutic properties, and the ability to manufacture these molecules cost-effectively.

Description

Keywords

Antivenom, Venom, Recombinant antivenom, Antibodies, Snakebite, Scorpion sting, Spider bite, Animal envenoming, Pharmacokinetics, Pharmacodynamics, Immunogenicity, Venom neutralization, Antibody expression, Antivenom design, Adverse reactions, Neglected tropical diseases, Biotechnology, 615.946 Venenos animales

Citation

https://www.sciencedirect.com/science/article/pii/S0041010118301144?via%3Dihub

Collections

Endorsement

Review

Supplemented By

Referenced By