Papel del estrés oxidativo en la esquizofrenia
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Raventós Vorst, Henriette
Soto Bernardini, María Clara
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Abstract
La esquizofrenia es una enfermedad mental severa que se presenta en alrededor del 1% de la
población mundial. Para que se manifieste son necesarios tanto factores genéticos como
ambientales, por lo que el genotipo de riesgo no conlleva al desarrollo de la enfermedad sino a
una mayor susceptibilidad de presentarla. Existe evidencia de que el balance entre la producción
de radicales libres y el sistema de defensa antioxidante está alterado en pacientes con esquizofrenia.
Sin embargo, no se sabe con certeza si la producción de RLs tiene un papel causal en el desarrollo
de la enfermedad o es producido durante el curso de la enfermedad, o por el uso de neurolépticos.
En este artículo se revisa la evidencia de la participación de estas sustancias en el desarrollo de
la enfermedad.
Schizophrenia is a severe mental disorder that affects approximately 1% of the population worldwide. Genetic and environmental factors are important in its etiology, so the risk genotype increases the susceptibility to manifest the disorder. There is evidence that the balance between the production of free radicals and the antioxidant defense system is abnormal in schizophrenia patients. Nonetheless, it is not known if it plays a causal role in the development of the disorder, or if it is produced during the course of the disease, or as a consequence of antipsychotic treatment. In this paper, we review the evidence of the participation of these substances in the development of the illness.
Schizophrenia is a severe mental disorder that affects approximately 1% of the population worldwide. Genetic and environmental factors are important in its etiology, so the risk genotype increases the susceptibility to manifest the disorder. There is evidence that the balance between the production of free radicals and the antioxidant defense system is abnormal in schizophrenia patients. Nonetheless, it is not known if it plays a causal role in the development of the disorder, or if it is produced during the course of the disease, or as a consequence of antipsychotic treatment. In this paper, we review the evidence of the participation of these substances in the development of the illness.
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Estrés oxidativo, Esquizofrenia, Oxi-radicales, Sistema de defensa antioxidante, Oxidative stress, Schizophrenia, Oxyradicals, Antioxidant defense system, 616.898 2 Esquizofrenia y autismo
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https://actamedica.medicos.cr/index.php/Acta_Medica/article/view/3/3
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