Mostrar el registro sencillo del ítem
Insulin resistance and impaired glucose tolerance in overweight and obese Costa Rican schoolchildren
dc.creator | Holst Schumacher, Ileana | |
dc.creator | Núñez Rivas, Hilda Patricia | |
dc.creator | Monge Rojas, Rafael | |
dc.creator | Barrantes Santamaría, Mauro | |
dc.date.accessioned | 2018-10-19T20:26:24Z | |
dc.date.available | 2018-10-19T20:26:24Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | http://journals.sagepub.com/doi/abs/10.1177/156482650802900206 | |
dc.identifier.issn | 0379-5721 | |
dc.identifier.issn | 1564-8265 | |
dc.identifier.uri | https://hdl.handle.net/10669/76036 | |
dc.description.abstract | Background. Worldwide obesity has become an unprecedented public health challenge. In addition, a notable increase in the risk of insulin resistance and type 2 diabetes mellitus has emerged. In Costa Rica, there are no epidemiological data to establish the prevalence of type 2 diabetes in the pediatric population. However, information from the Endocrinology Department of the Children’s National Hospital indicates an increased number of cases in the last 2 to 3 years. Objective. To determine the prevalence of insulin resistance and impaired glucose tolerance in overweight and obese schoolchildren. Methods. This cross-sectional study was conducted among 214 healthy 8- to 10-year-old children from urban schools of San José, Costa Rica. Anthropometric measurements and blood determinations of glucose, insulin, proinsulin, glycosylated hemoglobin, C-peptide, and leptin were performed. Indexes were calculated to assess insulin resistance. Information on social and lifestyle variables was obtained from questionnaires, and acanthosis nigricans was certified by a physician. Statistical analysis was performed with SPSS software for Windows, version 10.0. Results. The prevalence of type 2 diabetes mellitus was very low (0.5%) in the studied population. However, hyperinsulinemia and impaired glucose tolerance were present in 20.6% and 6.5% of the subjects, respectively. On the basis of the Fasting Glucose-to-Insulin Resistance Ratio (FGIR), 46.7% of the children showed insulin resistance. Girls and obese children (body mass index ≥ 95th percentile) were more likely to have higher serum insulin levels and insulin resistance than boys and overweight children (BMI ≥ 85th percentile). Compared with the lowest quintile, children in the highest quintile of body-fat tissue had higher insulin resistance but had similar serum concentrations of glucose, C-peptide, and proinsulin. Positive family histories of type 2 diabetes mellitus and sedentarism (73.7% and 40.7%, respectively) were highly prevalent among overweight and obese children. Conclusions. The prevalence of impaired glucose tolerance and insulin resistance in obese children indicates a worrisome trend in the incidence of type 2 diabetes in Costa Rica. Strategies for weight reduction, obesity prevention, and promotion of healthy lifestyles are necessary to prevent the onset of type 2 diabetes during childhood and adolescence. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica/[807-A3-305]/UCR/Costa Rica | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Food and Nutrition Bulletin, Vol. 29(2), pp.123-131 | es_ES |
dc.subject | Childhood obesity | es_ES |
dc.subject | Diabetes mellitus type 2 | es_ES |
dc.subject | FGIR | es_ES |
dc.subject | HOMA-IR | es_ES |
dc.subject | Hyperinsulinemia | es_ES |
dc.subject | Impaired glucose tolerance | es_ES |
dc.subject | Insulin resistance | es_ES |
dc.subject | QUICKI | es_ES |
dc.subject | Daibetes | es_ES |
dc.title | Insulin resistance and impaired glucose tolerance in overweight and obese Costa Rican schoolchildren | es_ES |
dc.type | artículo original | |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiología | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Hematología y Trastornos Afines (CIHATA) | es_ES |
dc.identifier.codproyecto | 807-A3-305 |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Microbiología [1171]