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Molecular epidemiology and antimicrobial resistance of Clostridium difficile in a national geriatric hospital in Costa Rica
dc.creator | Jiménez Solís, Andrea | |
dc.creator | Araya, R. | |
dc.creator | Paniagua Hidalgo, Diana | |
dc.creator | Camacho Mora, Zianne | |
dc.creator | Du, Tim | |
dc.creator | Golding, Geroge R. | |
dc.creator | Leandro Astorga, Gustavo | |
dc.creator | Rodríguez Sánchez, César | |
dc.creator | Quesada Gómez, Carlos | |
dc.date.accessioned | 2018-07-05T20:16:56Z | |
dc.date.available | 2018-07-05T20:16:56Z | |
dc.date.issued | 2018-08 | |
dc.identifier.citation | https://www.sciencedirect.com/science/article/pii/S0195670118301786?via%3Dihub#! | |
dc.identifier.issn | 0195-6701 | |
dc.identifier.uri | https://hdl.handle.net/10669/75163 | |
dc.description.abstract | Background: the epidemiology of Clostridium difficile infections (CDI) is changing rapidly worldwide; knowledge on the genotypes of C. difficile circulating in specialized geriatric hospitals and their resistance to antibiotics is scarce or non-existent. Methods: prospective study of the molecular epidemiology of CDI, conducted in a national geriatric hospital in Costa Rica for a period of 11 months. Results: the study patients exhibited a diverse range of comorbidities, but none were associated with CDI. Polyclonality, including three new ribotypes, and a high level of resistance to antibiotics were determined by analysing the 32 isolates obtained in these cases. Despite the diversity in strains observed, the most frequent types were NAP6/RT002 and NAP2/RT001. NAP9/RT017 was associated with community acquisition. Nineteen types of antimicrobials were used before the onset of diarrhoea in the patients; no particular genotype was associated with the onset of infection or severity. Conclusion: based on the abundance of strain types observed and their resistance to antibiotics in this geriatric hospital, these results contribute to a better overall understanding of the epidemiology of CDI worldwide, and to surveillance programmes targeting geriatric populations. | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Journal of Hospital Infection, Vol 99(4), pp 1-6 | es_ES |
dc.subject | Clostridium difficile | es_ES |
dc.subject | Geriatrics | es_ES |
dc.subject | Novel genotypes | es_ES |
dc.subject | Antibiotic resistance | es_ES |
dc.subject | 589.957 286 Clostridium | es_ES |
dc.title | Molecular epidemiology and antimicrobial resistance of Clostridium difficile in a national geriatric hospital in Costa Rica | es_ES |
dc.type | artículo original | |
dc.date.updated | 2018-06-06T14:55:10Z | |
dc.identifier.doi | 10.1016/j.jhin.2018.03.027 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET) | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiología | es_ES |
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Microbiología [1171]