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dc.creatorJiménez Solís, Andrea
dc.creatorAraya, R.
dc.creatorPaniagua Hidalgo, Diana
dc.creatorCamacho Mora, Zianne
dc.creatorDu, Tim
dc.creatorGolding, Geroge R.
dc.creatorLeandro Astorga, Gustavo
dc.creatorRodríguez Sánchez, César
dc.creatorQuesada Gómez, Carlos
dc.date.accessioned2018-07-05T20:16:56Z
dc.date.available2018-07-05T20:16:56Z
dc.date.issued2018-08
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0195670118301786?via%3Dihub#!es_ES
dc.identifier.issn0195-6701
dc.identifier.urihttp://hdl.handle.net/10669/75163
dc.description.abstractBackground: the epidemiology of Clostridium difficile infections (CDI) is changing rapidly worldwide; knowledge on the genotypes of C. difficile circulating in specialized geriatric hospitals and their resistance to antibiotics is scarce or non-existent. Methods: prospective study of the molecular epidemiology of CDI, conducted in a national geriatric hospital in Costa Rica for a period of 11 months. Results: the study patients exhibited a diverse range of comorbidities, but none were associated with CDI. Polyclonality, including three new ribotypes, and a high level of resistance to antibiotics were determined by analysing the 32 isolates obtained in these cases. Despite the diversity in strains observed, the most frequent types were NAP6/RT002 and NAP2/RT001. NAP9/RT017 was associated with community acquisition. Nineteen types of antimicrobials were used before the onset of diarrhoea in the patients; no particular genotype was associated with the onset of infection or severity. Conclusion: based on the abundance of strain types observed and their resistance to antibiotics in this geriatric hospital, these results contribute to a better overall understanding of the epidemiology of CDI worldwide, and to surveillance programmes targeting geriatric populations.es_ES
dc.language.isoen_USes_ES
dc.sourceJournal of Hospital Infection, Vol 99(4), pp 1-6es_ES
dc.subjectClostridium difficilees_ES
dc.subjectGeriatricses_ES
dc.subjectNovel genotypeses_ES
dc.subjectAntibiotic resistancees_ES
dc.subject589.957 286 Clostridiumes_ES
dc.titleMolecular epidemiology and antimicrobial resistance of Clostridium difficile in a national geriatric hospital in Costa Ricaes_ES
dc.typeartículo científicoes_ES
dc.date.updated2018-06-06T14:55:10Z
dc.identifier.doi10.1016/j.jhin.2018.03.027
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiologíaes_ES


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