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dc.creatorVélez, Sara María
dc.creatorSalazar, Marcos H.
dc.creatorAcosta de Patiño, Hildaura
dc.creatorGómez de González, Leandra Yolanda
dc.creatorRodriguez, Abdiel
dc.creatorCorrea, David
dc.creatorSaldaña, Julio
dc.creatorNavarro, Deyvi
dc.creatorLomonte, Bruno
dc.creatorOtero Patiño, Rafael
dc.creatorGutiérrez, José María
dc.date.accessioned2018-06-01T17:13:29Z
dc.date.available2018-06-01T17:13:29Z
dc.date.issued2017-06
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0041010117301186?via%3Dihub#!es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/74789
dc.description.abstractBothrops asper is the medically most important venomous snake in Central America. In Panama, the country having the highest incidence of snakebites in Latin America, B. asper is widely distributed throughout the country and is responsible for the vast majority of snakebites. This study was performed to analyze whether there are variations in the toxicological profile and in some biochemical parameters between the venoms of B. asper from four different regions in Panama. The venoms showed a similar profile of lethal, hemorrhagic, in vitro coagulant, defibrinogenating, edema-forming, myotoxic and indirect hemolytic activities, with subtle quantitative variations between samples of some regions. The venoms also had similar SDS-PAGE patterns and reverse phase HPLC profiles. A polyvalent antivenom manufactured in Costa Rica, and regularly used in Panama, was effective in the neutralization of lethal activity of the venoms of the four populations, with Mean Effective Doses (ED50) ranging from 5.98 to 9.72 mg venom/mL antivenom. In agreement, a widespread pattern of cross-reactivity between this antivenom and the four venoms was observed by immunoblotting. Overall, results highlight the lack of marked differences between the venoms of the various populations of B. asper in Panama, and that the antivenom from Costa Rica is effective in neutralizing lethality.es_ES
dc.description.sponsorshipSecretaría Nacional de Ciencia y Tecnología/[ INF10-051]/SENACYT/Panamáes_ES
dc.description.sponsorshipSecretaría Nacional de Ciencia y Tecnología/[COL06-017]/SENACYT/Panamáes_ES
dc.description.sponsorshipUniversidad de Panamá/[VIP-UP CUFI-2015-CS-P-010]/UP/Panamáes_ES
dc.description.sponsorshipUniversidad de Panamá/[VIP-01-04-15-2016-01]/UP/Panamáes_ES
dc.description.sponsorshipUniversidad de Panamá/[CE-PT-327-15-02-15-33]/UP/Panamáes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon, Vol 132, pp 55-61es_ES
dc.subjectPanamaes_ES
dc.subjectBothrops asperes_ES
dc.subjectAntivenomes_ES
dc.subjectNeutralizationes_ES
dc.subjectToxicityes_ES
dc.subjectSnake venomes_ES
dc.subject571.95 Toxicologíaes_ES
dc.titleGeographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2017.04.002
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid28392273


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