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dc.creatorSoares, Andreimar Martins
dc.creatorTicli, Fábio K.
dc.creatorMarcussi, Silvana
dc.creatorLourenço, Miriam V.
dc.creatorJanuário, Ana Helena
dc.creatorSampaio, Suely V.
dc.creatorGiglio, José Roberto
dc.creatorLomonte, Bruno
dc.creatorPereira, Paulo S.
dc.date.accessioned2018-02-27T21:44:32Z
dc.date.available2018-02-27T21:44:32Z
dc.date.issued2005
dc.identifier.citationhttp://www.eurekaselect.com/60333/articlees_ES
dc.identifier.issn1875-533X
dc.identifier.issn0929-8673
dc.identifier.urihttp://hdl.handle.net/10669/74166
dc.description.abstractEnvenomations due to snake bites are commonly treated by parenteral administration of horse or sheep-derived polyclonal antivenoms aimed at the neutralization of toxins. However, despite the widespread success of this therapy, it is still important to search for different venom inhibitors, either synthetic or natural, that could complement or substitute for the action of antivenoms. Several plants have been utilized in folk medicine as antiophidian. However, only a few species have been scientifically investigated and still less had their active components isolated and characterized both structurally and functionally. This article presents a review of plants showing neutralizing properties against snake venoms which were assayed in research laboratories, correlating them with ethnopharmacological studies, as (i) the part of the plant used as antidote, (ii) its respective genus and family and (iii) inhibition of the main pharmacological, toxic and enzymatic activities of snake venoms and isolated toxins. Protective activity of many of these plants against the lethal action of snake venoms has been confirmed by biological assays. Compounds in all of them belong to chemical classes capable of interacting with macromolecular targets (enzymes or receptors). Popular culture can often help to guide scientific studies. In addition, biotechnological application of these inhibitors, as helpful alternative or supplemental treatments to serum therapy, and also as important models for synthesis of new drugs of medical interest, needs to be better oriented and scientifically explored.es_ES
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo/[]/FAPESP/Brasiles_ES
dc.description.sponsorshipConsejo Nacional de Desarrollo Científico y Tecnológico/[]/CNPq/Brasiles_ES
dc.description.sponsorshipFundação José Pedro de Araújo/[]/FJPA/Brasiles_ES
dc.description.sponsorshipUniversidade de Ribeirão Preto/[]/UNAERP/Brasiles_ES
dc.language.isoen_USes_ES
dc.sourceCurrent Medicinal Chemistry 12, 2625-2641 (2005)es_ES
dc.subjectSnake venomes_ES
dc.subjectMedicinal plantses_ES
dc.subjectantiophidian plantses_ES
dc.subjectanti-snake venomes_ES
dc.subjecttoxin inhibitorses_ES
dc.subjectethnopharmacological studieses_ES
dc.titleMedicinal plants with inhibitory properties against snake venomses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.2174/092986705774370655
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid16248818


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