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dc.creatorValerio Aguilar, Daniel
dc.creatorRaventós Vorst, Henriette
dc.creatorSchmeidler, James
dc.creatorBeeri, Michal S.
dc.creatorMora Villalobos, Lara
dc.creatorBolaños Palmieri, Patricia
dc.creatorCarrión Baralt, José R.
dc.creatorFornaguera Trías, Jaime
dc.creatorSilverman, Jeremy M.
dc.date.accessioned2018-01-23T15:13:31Z
dc.date.available2018-01-23T15:13:31Z
dc.date.issued2014-10
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S1064748114001080?via%3Dihub#!es_ES
dc.identifier.issn1064-7481
dc.identifier.urihttp://hdl.handle.net/10669/73972
dc.description.abstractTo study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample). In both case-control studies, participants were cognitively intact or diagnosed with dementia. The N-sample (N = 112) was at least age 90 years; the GE-sample (N = 98) was at least age 65 years. Dementia and APOE-e4 were not significantly associated in the N-sample, but were in the GE-sample. There was a significant interaction of age with APOE-e4 in the N-sample, but not in the GE-sample. Descriptively dividing the N-sample at the median (age 93 years) showed a group interaction: APOE-e4 was more associated with dementia in the younger N-sample than in the older N-sample, where six of seven APOE-e4 carriers were cognitively intact. The results support the reduction in association of APOE-e4 with dementia in extreme old age, consistent with a survivor effect model for successful cognitive aging.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[]/UCR/Costa Ricaes_ES
dc.description.sponsorshipFogarty International Center/[]/NIH/Estados Unidoses_ES
dc.description.sponsorshipNational Institute on Aging/[R21TW009258]/NIH/Estados Unidoses_ES
dc.description.sponsorshipAlzheimer’s Association/[]//Estados Unidoses_ES
dc.language.isoeses_ES
dc.sourceThe American Journal of Geriatric Psychiatry. Vol. 22 (10), pp. 957-960es_ES
dc.subjectSuccessful cognitive aginges_ES
dc.subjectOldest-oldes_ES
dc.subjectDementia risk factorses_ES
dc.titleAssociation of Apolipoprotein E-e4 and Dementia Declines with Agees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.jagp.2014.03.008
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)es_ES
dc.description.procedenceUCR::Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es_ES
dc.description.procedenceUCR::Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologíaes_ES


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