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dc.creatorLeite, R. S.
dc.creatorGiuliani, C. D.
dc.creatorLomonte, Bruno
dc.creatorFranco, Wilfredo
dc.creatorSelistre de Araujo, Heloisa S.
dc.date.accessioned2018-01-15T16:21:03Z
dc.date.available2018-01-15T16:21:03Z
dc.date.issued2004
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010104002120es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/73856
dc.description.abstractThe aim of this work was to study the effect of recombinant ACL myotoxin, a Lys49PLA2 from Agkistrodon contortrix laticinctus snake venom and Lys49PLA2-derived synthetic peptides corresponding to the region 115–129 of venom of the two different Agkistrodon species on water permeability in the toad urinary bladder. The water flow through the membrane was measured gravimetrically in bag preparations of the bladder. The addition of recombinant ACL myotoxin-MBP (maltose binding protein) fusion protein (10 nM) to the bathing solution significantly increased (above 60%) the water transport compared with the control hemibladders. The addition of the Lys49PLA2-derived synthetic peptides in several concentrations to the bathing solution did not affect the water transport across membrane. These results suggest that the ACL myotoxin effect on water transport is not related to the cytotoxic C-terminal region.es_ES
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel/[]/CAPES/Braziles_ES
dc.language.isoen_USes_ES
dc.sourceToxicon, vol.44 (2), pp.157-159es_ES
dc.subjectLys49 phospholipase A2es_ES
dc.subjectWater transportes_ES
dc.subjectToad bladderes_ES
dc.subjectSynthetic peptideses_ES
dc.subjectSnake venomes_ES
dc.titleEffect of a recombinant Lys49 PLA2 myotoxin and Lys49 PLA2-derived synthetic peptides from Agkistrodon species on membrane permeability to water.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2004.05.013
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid15284020


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