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dc.creatorFornaguera Trías, Jaime
dc.creatorSchwarting, Rainer K. W.
dc.date.accessioned2017-12-13T21:52:50Z
dc.date.available2017-12-13T21:52:50Z
dc.date.issued2002
dc.identifier.citationhttps://link.springer.com/article/10.1080%2F10298420290007619es_ES
dc.identifier.issn1029-8428
dc.identifier.urihttp://hdl.handle.net/10669/73686
dc.description.abstractIn this study, the degree and time course of deficits in open field behavior was analyzed in male Wistar rats (aged 1 year) which had received unilateral neostriatal lesions with 6-OHDA. The post-mortem neurochemical analysis showed that dopamine was partly depleted in the lateral (to 45%), and in the medial neostriatum (65%). In spontaneous (i.e. undrugged) open field behavior, lesion-dependent asymmetries were observed in turning and scanning. The time courses of asymmetry differed between the two measures, since pronounced ipsiversive asymmetries in turning were observed within the first days after lesion placement and persisted throughout the postoperative testing period of 30 days, whereas the ipsilateral asymmetry in scanning appeared during the first week and remained stable thereafter. Systemic treatment with the dopamine receptor agonist apomorphine reversed the asymmetry in turning, indicating supersensitivity of postsynaptic neostriatal dopamine receptors. Furthermore, an enhanced grooming response to apomorphine was measured; however, only in those animals with the more severe 6-OHDA lesions. These findings are discussed in comparison to those obtained with 6-OHDA lesions placed at the level of dopamine cell bodies or fibers, the role of neostriatal dopamine depletion, and the possible relationships with progressive neurodegeneration.es_ES
dc.description.sponsorshipGerman Academic Exchange Service/[]/DAAD/Alemaniaes_ES
dc.description.sponsorshipDeutsche Forschungsgemeinschaft/[]/DFG/Alemaniaes_ES
dc.language.isoen_USes_ES
dc.sourceNeurotoxicity Research, Vol. 4 (1), pp 41–49es_ES
dc.subjectTurninges_ES
dc.subjectThigmotactic scanninges_ES
dc.subjectLocomotiones_ES
dc.subject6-Hydroxydopaminees_ES
dc.subjectDopaminees_ES
dc.subjectApomorphinees_ES
dc.subjectParkinson's diseasees_ES
dc.subjectRecoveryes_ES
dc.titleTime course of deficits in open field behavior after unilateral neostriatal 6-hydroxydopamine lesionses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1080/10298420290007619
dc.description.procedenceUCR::Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.identifier.pmid12826492


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