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dc.creatorFarina, Marcelo
dc.creatorCereser, Víctor
dc.creatorPortela, Luis V.
dc.creatorMendez, Andreas
dc.creatorPorciuncula, L. O.
dc.creatorFornaguera Trías, Jaime
dc.creatorGonçalves, C. A.
dc.creatorWofchuk, S. T.
dc.creatorRocha, Joao Batista Teixeira
dc.creatorSouza, D. O.
dc.date.accessioned2017-12-13T21:38:34Z
dc.date.available2017-12-13T21:38:34Z
dc.date.issued2005-02
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S1382668904001735es_ES
dc.identifier.issn1382-6689
dc.identifier.urihttp://hdl.handle.net/10669/73684
dc.description.abstractS100B, a calcium binding protein physiologically produced and released by astrocytes, has been used as a peripheral marker of brain damage. Here, we investigated the effects of subcutaneous injections of methylmercury chloride (MeHg–5 mg/kg), an environmental neurotoxicant, on S100B protein content in cerebrospinal fluid (CSF) of adult rats. In addition, the performance of animals in an open field (number of squares crossing and rearings) was also analyzed in order to obtain a possible link between alteration in S100B protein content in CSF and parameters related to neurological injury. MeHg treatment increased serum mercury and S100B protein levels in the CSF. A decrease in the numbers of crossings and rearings was observed in MeHg-treated animals when compared to control group, which suggests a possible neurological injury. The present data show, for the first time, increased S100B levels in CSF after exposure to a neurotoxic metal. Authors discuss the possibility of astrocytic involvement in MeHg-induced neurotoxicity.es_ES
dc.description.sponsorshipPan American Health Organization/[]/OPS/Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceEnvironmental Toxicology and Pharmacology. Vol.19 (2), pp. 249-253es_ES
dc.subjectMethylmercuryes_ES
dc.subjectS100Bes_ES
dc.subjectNeurotoxicityes_ES
dc.subjectAstrocyteses_ES
dc.subjectReactive gliosises_ES
dc.titleMethylmercury increases S100B content in rat cerebrospinal fluides_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.etap.2004.07.008
dc.description.procedenceUCR::Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.identifier.pmid21783483


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