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dc.creatorBrenes Sáenz, Juan Carlos
dc.creatorRodríguez Villagra, Odir Antonio
dc.creatorFornaguera Trías, Jaime
dc.date.accessioned2017-12-13T19:56:25Z
dc.date.available2017-12-13T19:56:25Z
dc.date.issued2006
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0166432805005383es_ES
dc.identifier.issn0166-4328
dc.identifier.urihttp://hdl.handle.net/10669/73683
dc.description.abstractDevelopmental and social factors are known to play a crucial role in the pathogenesis of affective disorders. Although it has been demonstrated that early life aversive experiences can be a risk factor in the development of human depression, most of the investigation in animals that try to model depression do not include postnatal manipulations. Since housing represents a fundamental ethological factor which modifies behavior and brain development, this study aimed to investigate the impact of different social and structural housing conditions on the development of a depressive-like syndrome in the behavioral despair paradigm and an anxiety-like syndrome in the unconditioned anxiety paradigm. The present study uses several multivariate analyses to study the impact of housing conditions in animal models of depression and anxiety. In this study, social isolation was able to reproduce the effects found in other animals models based on stress, suggesting that only 2 months of social isolation are enough to produce effects that can be useful as behavioral model of depression. Moreover, environmental enrichment showed an antidepressive and anxiolytic like effect in animal models of depression and anxiety. This effect, which has not been reported in earlier studies, suggests that stimulation during the first stages of growth might play a “protective” role on behavior and brain development.es_ES
dc.description.sponsorshipVicerrectoría de Investigación Universidad de Costa Rica/[605-A3-953]/VINV/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceBehavioural Brain Research, Vol. 169 (1), pp. 57-65es_ES
dc.subjectEnvironmental enrichmentes_ES
dc.subjectSocial isolationes_ES
dc.subjectForced Swimming testes_ES
dc.subjectOpen Field testes_ES
dc.subjectSucrose Preference testes_ES
dc.subjectFactor analysises_ES
dc.titleFactor analysis of Forced Swimming test, Sucrose Preference test and Open Field test on enriched, social and isolated reared ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.bbr.2005.12.001
dc.description.procedenceUCR::Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.identifier.pmid16414129


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